7-chloro-6-ethyl-5,8-dihydroxy-2,3-dimethyl-1,4-dihydronaphthalene-1,4-dione | 1331827-36-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-chloro-6-ethyl-5,8-dihydroxy-2,3-dimethyl-1,4-dihydronaphthalene-1,4-dione
• CAS: 1331827-36-1
• 化学式: C₁₄H₁₃ClO₄
• 分子量: 280.708
• InChiKey: KGWLVAJMSKWJMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.03
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  74.6
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-乙基-1,4-二甲氧基苯 在 盐酸 、 manganese(IV) oxide 、 aluminum (III) chloride 、 sodium dithionite 、 sodium chloride 、 potassium hydroxide 作用下， 以 水 、 溶剂黄146 、 乙酸乙酯 为溶剂， 反应 1.25h， 生成 7-chloro-6-ethyl-5,8-dihydroxy-2,3-dimethyl-1,4-dihydronaphthalene-1,4-dione
  参考文献：
  名称：

  Chlorination of 2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones with HCl-MnO2 in acetic acid. effective transformation of 2,3,6-trialkyl-2,3,7-trichloro-1,2,3,4-tetrahydronaphthalene-1,4-diones into 7-chloro-2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones

  摘要：

  Chlorination of 2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones with HCl-MnO2 in acetic acid gave a mixture of 7-chloro-2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones and 2,3,7-trichloro-2,3,6-trialkyl-1,2,3,4-tetrahydronaphthalene-1,4-diones, the latter being formed via addition of the second chlorine molecule to monochloro derivatives. The reduction of 2,3,7-trichloro-2,3,6-trialkyl-1,2,3,4-tetrahydronaphthalene-1,4-diones with sodium dithionite in alkaline medium resulted in the formation of 7-chloro-2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones in high yield.

  DOI：

  10.1134/s1070428011070128

文献信息

• Chlorination of 2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones with HCl-MnO2 in acetic acid. effective transformation of 2,3,6-trialkyl-2,3,7-trichloro-1,2,3,4-tetrahydronaphthalene-1,4-diones into 7-chloro-2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones
  作者：N. S. Polonik、S. G. Polonik、V. A. Denisenko、O. P. Moiseenko、V. F. Anufriev

  DOI：10.1134/s1070428011070128

  日期：2011.7

  Chlorination of 2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones with HCl-MnO2 in acetic acid gave a mixture of 7-chloro-2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones and 2,3,7-trichloro-2,3,6-trialkyl-1,2,3,4-tetrahydronaphthalene-1,4-diones, the latter being formed via addition of the second chlorine molecule to monochloro derivatives. The reduction of 2,3,7-trichloro-2,3,6-trialkyl-1,2,3,4-tetrahydronaphthalene-1,4-diones with sodium dithionite in alkaline medium resulted in the formation of 7-chloro-2,3,6-trialkyl-5,8-dihydroxy-1,4-naphthoquinones in high yield.