N1,n1-二甲基环己烷-1,4-二胺双盐酸盐 | 1031289-75-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N1,n1-二甲基环己烷-1,4-二胺双盐酸盐
• 英文名称: N1,N1-Dimethylcyclohexane-1,4-diamine dihydrochloride
• 英文别名: 4-N,4-N-dimethylcyclohexane-1,4-diamine;dihydrochloride
• CAS: 1031289-75-4
• 化学式: C8H20Cl2N2
• 分子量: 215.16
• InChiKey: HRZUCSCEEZQGMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.66
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] IRAK INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS D'IRAK ET LEURS UTILISATION
  申请人：NIMBUS IRIS INC

  公开号：WO2012097013A1

  公开（公告）日：2012-07-19

  The present invention relates to compounds and methods useful for inhibiting one or more interleukin-l receptor-associated kinases ("IRAK"). In some embodiments, a provided compound inhibits IRAK-1 and IRAK-4. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

  本发明涉及化合物和方法，用于抑制一个或多个白细胞介素-1受体相关激酶（"IRAK"）。在某些实施例中，所提供的化合物抑制IRAK-1和IRAK-4。该发明还提供了包括本发明化合物的药学上可接受的组合物，以及使用所述组合物治疗各种疾病的方法。
• Phenyl-Heteroaryl Derivatives and Methods of Use Thereof
  申请人：TransTech Pharma, Inc.

  公开号：US20130197007A1

  公开（公告）日：2013-08-01

  The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

  本发明提供了式（I）的苯基-杂环芳基衍生物及其药学上可接受的盐。这些化合物可用于治疗RAGE介导的疾病，如阿尔茨海默病。本发明还涉及制备式（I）的化合物及其药学上可接受的盐的方法，包括这种化合物的制药组合物，以及使用这种化合物和/或制药组合物治疗RAGE介导的疾病。
• IRAK INHIBITORS AND USES THEREOF
  申请人：NIMBUS IRIS, INC.

  公开号：US20130231328A1

  公开（公告）日：2013-09-05

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用它们的方法。
• NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP3885348A1

  公开（公告）日：2021-09-29

  The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases or tumors, containing, as an active ingredient, a tricyclic compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof, and a health food composition for preventing or alleviating autoimmune diseases or tumors, containing the tricyclic compound as an active ingredient. The tricyclic compound represented by Chemical Formula 1 of the present invention has an excellent inhibitory activity against IRAK4, and thus can be usefully used for the prevention, treatment, or alleviation of autoimmune diseases or tumors.

  本发明涉及一种用于预防或治疗自身免疫性疾病或肿瘤的药物组合物，其活性成分含有下化学式 1 所代表的三环化合物或其药学上可接受的盐，以及一种用于预防或缓解自身免疫性疾病或肿瘤的保健食品组合物，其活性成分含有该三环化合物。 本发明化学式 1 所代表的三环化合物对 IRAK4 具有极好的抑制活性，因此可有效地用于预防、治疗或缓解自身免疫性疾病或肿瘤。
• Benzamide compounds
  申请人：Recurium IP Holdings, LLC

  公开号：US11318134B2

  公开（公告）日：2022-05-03

  Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV.

  本研究提供了具有式(I)的化合物。此类化合物、及其药学上可接受的盐和组合物，可用于治疗各种疾病或病症，包括以细胞过度增殖为特征的疾病，如癌症和肿瘤，以及病毒性感染，如HIV。