N-[1-cyano-4-(4-hydroxy-3,5-dimethoxyphenyl)buta-1,3-dienyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[1-cyano-4-(4-hydroxy-3,5-dimethoxyphenyl)buta-1,3-dienyl]acetamide
• 化学式: C₁₅H₁₆N₂O₄
• 分子量: 288.3
• InChiKey: PKKMZLZOABYCON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  91.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel compounds for modulating cell proliferation
  申请人：——

  公开号：US20030109502A1

  公开（公告）日：2003-06-12

  Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: 1

  揭示了一种在治疗多种细胞增殖性疾病如癌症中有用的新型苯乙烯丙腈化合物。这些化合物的化学式为I：1。
• Inhibition of vascular endothelial growth factor
  申请人：Roifman M. Chaim

  公开号：US20060241084A1

  公开（公告）日：2006-10-26

  This invention relates to therapeutic organic compounds and inhibition of secretion of vascular endothelial growth factor (VEGF) and its effects, including angiogenesis.

  本发明涉及治疗有机化合物和抑制血管内皮生长因子（VEGF）分泌及其效应，包括血管生成。
• Compounds for modulating cell proliferation
  申请人：HSC Research and Development Limited Partnership

  公开号：EP1752446A2

  公开（公告）日：2007-02-14

  Novel styrylacrylonitrile compounds and a pharmaceutical composition comprising a compound of Formula II or a salt, solvate, or hydrate thereof: wherein R1 and R2 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S-C1-6alkyl, O-Si(C1-6alkyl)(C1-6alkyl)(C1-6alkyl), NO2, CF3, OCF3 and halo; R3 is selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S-C1-6alkyl, O-Si(C1-6alkyl)(C1-6alkyl)(C1-6alkyl), NO2, halo and CH2-S-(CH2)n Ar; Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents, independently selected from OH, C1-6alkyl, C1-6alkoxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S-C1-6alkyl, NO2, CF3, OCF3 and halo; R6 is selected from Ar, OH and OC1-6alkyl; X is selected from O and S; n is 0-4; and p is 1-4, and conventional esters thereof formed with available hydroxy, amino or carboxyl groups. The pharmaceutical composition is useful in treating a variety of cell proliferative disorders such as cancer.

  新型苯乙烯-丙烯腈化合物和包含式 II 化合物或其盐、溶液或水合物的药物组合物： 其中 R1 和 R2 各自独立地选自 H、OH、C1-6烷基、C1-6烷氧基、NH2、NH-C1-6烷基、N(C1-6烷基)(C1-6烷基)、SH、S-C1-6烷基、O-Si(C1-6烷基)(C1-6烷基)(C1-6烷基)、NO2、CF3、OCF3 和卤素；R3 选自 H、OH、C1-6烷基、C1-6烷氧基、NH2、NH-C1-6烷基、N(C1-6烷基)(C1-6烷基)、SH、S-C1-6烷基、O-Si(C1-6烷基)(C1-6烷基)(C1-6烷基)、NO2、卤素和 CH2-S-(CH2)n Ar；R6 选自 Ar、OH 和 OC1-6烷基；X 选自 O 和 S；n 为 0-4；p 为 1-4，以及其与可用的羟基、氨基或羧基形成的常规酯。该药物组合物可用于治疗各种细胞增殖性疾病，如癌症。
• COMPOUNDS FOR MODULATING CELL PROLIFERATION
  申请人：HSC Research and Development Limited Partnership

  公开号：EP1272457A2

  公开（公告）日：2003-01-08
• JP2003531133A
  申请人：——

  公开号：JP2003531133A

  公开（公告）日：2003-10-21