1-(2,4-dimethylcyclopentyl)-N-methylmethanamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(2,4-dimethylcyclopentyl)-N-methylmethanamine
• 化学式: C₉H₁₉N
• 分子量: 141.25
• InChiKey: KERMIKBSVSJAJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] PROCESSES FOR THE PREPARATION OF A KINASE INHIBITOR<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN INHIBITEUR DE KINASE
  申请人：EXELIXIS INC

  公开号：WO2021222673A1

  公开（公告）日：2021-11-04

  The present invention relates to processes for the synthetic preparation of c-Met inhibitors of Formula I, or pharmaceutically acceptable salts thereof. The present invention further relates to processes for the synthetic preparation of the c-Met inhibitor, Compound 1, or a pharmaceutically acceptable salt thereof. The present invention also relates to processes for the synthetic preparation of Compound 1·hemifumarate. The invention further relates to large scale processes for the synthetic preparation of the c-Met inhibitor, Compound 1 and Compound 1·hemifumarate.

  本发明涉及一种合成c-Met抑制剂I式化合物或其药学上可接受的盐的方法。本发明还涉及合成c-Met抑制剂化合物1或其药学上可接受的盐的方法。本发明还涉及合成化合物1·半富马酸盐的方法。该发明还涉及大规模合成c-Met抑制剂化合物1和化合物1·半富马酸盐的方法。
• Biomarker identification
  申请人：ImmuneXpress Pty Ltd

  公开号：US10190169B2

  公开（公告）日：2019-01-29

  Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected of suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS.

  所公开的是用于鉴定生物标记物的方法和装置，特别是用于鉴定生物标记物的方法和装置，这些生物标记物可用于临床评估，如早期诊断、诊断、疾病分期、疾病严重程度、疾病亚型、对治疗的反应或预后评估。在一个特定的例子中，这些技术可用于评估患有、疑似患有或有 SIRS（全身炎症反应综合征）临床症状的病人，这些病人要么是感染阴性 SIRS，要么是感染阳性 SIRS。
• BENZOCYCLOHEPTANETHIOPHENE DERIVATIVES FOR ANTI-ALLERGIC REACTIONS
  申请人：Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd.

  公开号：EP2727919B1

  公开（公告）日：2019-05-08
• INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE
  申请人：Exelixis, Inc.

  公开号：EP2616442B1

  公开（公告）日：2018-08-08
• DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES
  申请人：Exelixis, Inc.

  公开号：EP2621481B1

  公开（公告）日：2019-08-14