4-(3-Hydroxypropylamino)butan-1-ol | 79448-07-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(3-Hydroxypropylamino)butan-1-ol
• CAS: 79448-07-0
• 化学式: C₇H₁₇NO₂
• 分子量: 147.22
• InChiKey: RVJMTSHLIOIGNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Substituted quinazoline derivatives as inhibitors of aurora kinases
  申请人：Jung Henri Frederic

  公开号：US20050070561A1

  公开（公告）日：2005-03-31

  The invention provides quinazoline derivatives of formula (I): in the preparation of a medicament for use in the inhibition of Aurora kinase and also novel quinazoline derivatives, processes for their preparation, pharamceutical compositions containing them and their use in therapy.

  该发明提供了化学式（I）的喹唑啉衍生物：在制备用于抑制极化丝激酶的药物时，以及新的喹唑啉衍生物，它们的制备过程，包含它们的药物组合物以及它们在治疗中的使用。
• Substituted Quinazoline Derivatives as Inhibitors of Aurora Kinases
  申请人：Jung Frederic Henri

  公开号：US20090215770A1

  公开（公告）日：2009-08-27

  The invention provides quinazoline derivatives of formula (I): in the preparation of a medicament for use in the inhibition of Aurora kinase and also novel quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  该发明提供了式（I）的喹唑啉衍生物： 在制备用于抑制极化子激酶的药物时，以及新型喹唑啉衍生物，它们的制备过程，含有它们的制药组合物以及它们在治疗中的应用。
• Protein-Proteophor Complexes
  申请人：Complex Biosystems GmbH

  公开号：EP2090323A1

  公开（公告）日：2009-08-19

  The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.

  本申请涉及一种组合物，该组合物由连接到核心和生物活性分子的超支化聚合物组成。生物活性分子通过基本上不可酶解的连接体 L 连接到芯上。
• HYPERBRANCHED POLYMER CONJUGATES VIA NON-ENZYMATIC CLEAVABLE LINKER
  申请人：Ascendis Pharma Growth Disorders Division A/S

  公开号：EP3085388A1

  公开（公告）日：2016-10-26

  The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.

  本申请涉及一种组合物，该组合物由连接到核心和生物活性分子的超支化聚合物组成。 生物活性分子通过基本上不可酶解的连接体 L 连接到芯上。
• Carbostyril derivatives
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0382185B1

  公开（公告）日：1994-06-15