(8S,9S,10R,13S,14S,17S)-17-acetyl-1-hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8S,9S,10R,13S,14S,17S)-17-acetyl-1-hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₁H₂₈O₃
• 分子量: 328.4
• InChiKey: NPZZFNSPAOWSJJ-FDIQSBBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHOD AND COMPOSITIONS FOR TREATING GLIOBLASTOMA<br/>[FR] MÉTHODE ET COMPOSITIONS DE TRAITEMENT D'UN GLIOBLASTOME
  申请人：PHOENIX BIOTECHNOLOGY INC

  公开号：WO2021113027A1

  公开（公告）日：2021-06-10

  A method of treaing glioma is provided. A combination protocol as described herein includes radiotherapy, chemotherapy, and pharmacotherapy. Resection of the glioma is optionally included in the combination protocol. Pharmacotherapy is conducted with an oleandrin-containing composition. Treatment of glioblastoma is particularly contemplated.