(5E)-1-benzyl-5-[(5-chloro-2-hydroxyanilino)methylidene]-4-methyl-2,6-dioxopyridine-3-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (5E)-1-benzyl-5-[(5-chloro-2-hydroxyanilino)methylidene]-4-methyl-2,6-dioxopyridine-3-carbonitrile
• 化学式: C₂₁H₁₆ClN₃O₃
• 分子量: 393.8
• InChiKey: PQHTVDQCYGKSDR-GZTJUZNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  93.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITION OF HEPATOCYTE GROWTH FACTORY RECEPTOR C-MET SIGNALING
  申请人：The United States Of America, As Represented By The Secretary, Department Of Health & Human Services

  公开号：EP2271620A1

  公开（公告）日：2011-01-12
• COMPOSITIONS AND METHODS FOR INHIBITION OF HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET SIGNALING
  申请人：Bottaro Donald P.

  公开号：US20110190295A1

  公开（公告）日：2011-08-04

  Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.
• US8754081B2
  申请人：——

  公开号：US8754081B2

  公开（公告）日：2014-06-17
• [EN] COMPOSITIONS AND MEHTODS FOR INHIBITION OF HEPATOCYTE GROWTH FACTORY RECEPTOR C-MET SIGNALING<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE SIGNALISATION DE RÉCEPTEUR C-MET DE FACTEUR DE CROISSANCE D'HÉPATOCYTE
  申请人：US HEALTH

  公开号：WO2009124013A1

  公开（公告）日：2009-10-08

  Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.