(2E)-2-benzylidene-4H-1,4-benzoxazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: (2E)-2-benzylidene-4H-1,4-benzoxazin-3-one
• 化学式: C₁₅H₁₁NO₂
• 分子量: 237.25
• InChiKey: LIZJZQCYTCJLHF-GXDHUFHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 1, 4-Benzoxazine Compounds and Derivatives Thereof as Therapeutic Drugs for the Treatment of Neurodegenerative Conditions
  申请人：D'Mello Santosh R.

  公开号：US20120094991A1

  公开（公告）日：2012-04-19

  The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.

  本发明涉及抑制激酶活性的组合物和方法，以保护免受神经退行性疾病的影响，包括阿尔茨海默病、帕金森病或亨廷顿病，以及缺血性中风等病症，其中包括向患者提供一定量的1,4-苯并噁嗪化合物及其衍生物以达到治疗效果的步骤。
• 1,4-BENZOXAZINE COMPOUNDS AND DERIVATIVES THEREOF AS THERAPEUTIC DRUGS FOR THE TREATMENT OF NEURODEGENERATIVE CONDITIONS
  申请人：Board of Regents, The University of Texas System

  公开号：EP2328877A2

  公开（公告）日：2011-06-08
• US8680094B2
  申请人：——

  公开号：US8680094B2

  公开（公告）日：2014-03-25
• [EN] 1,4-BENZOXAZINE COMPOUNDS AND DERIVATIVES THEREOF AS THERAPEUTIC DRUGS FOR THE TREATMENT OF NEURODEGENERATIVE CONDITIONS<br/>[FR] COMPOSÉS DE 1,4-BENZOXAZINE, ET DÉRIVÉS DE CEUX-CI EN TANT QUE MÉDICAMENTS THÉRAPEUTIQUES POUR LE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS
  申请人：UNIV TEXAS

  公开号：WO2010019911A2

  公开（公告）日：2010-02-18

  The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.