申请人:TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
公开号:US20160242413A1
公开(公告)日:2016-08-25
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula
R
1
, R
2
, R
3
, R
4
, R
5
, R
6
, R
10
, or R
11
is H or a C
1-12
alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH
2
, —NHR′, —N—C(O)R′, —N—C(O)CR′═CR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF
3
, —OCF
3
, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R
7
, R
8
or R
9
is a C
1-12
alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH
2
, —NHR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF
3
, and —OCF
3
. R′ is H or a C
1-4
alkyl. X or Y is a halogen. m and n are integers in the range from 1 to 25.