Diethylazanium;2,5-dihydroxybenzene-1,4-disulfonate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Diethylazanium;2,5-dihydroxybenzene-1,4-disulfonate
• 英文别名: diethylazanium;2,5-dihydroxybenzene-1,4-disulfonate
• 化学式: C14H28N2O8S2
• 分子量: 416.5
• InChiKey: XYUSESXYUHHDPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.82
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  190
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• USE OF 2,5-DIHYDROXYBENZENESULPHONIC ACID DERIVATIVES IN THE PRODUCTION OF A MEDICAMENT USED TO POTENTIATE THE EFFECT OF OTHER DRUGS IN THE TREATMENT OF ERECTILE DYSFUNCTION
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1413332A1

  公开（公告）日：2004-04-28

  The present invention refers to the use of derivatives of 2,5-dihidroxybenzenosulphonic acids of general formula (I), to develop medicinal products of therapeutic value to enhance the effects of phosphodiesterase-5 including sildenaphyl, vardenaphyl and IC-351, of apomorphine, of nitric oxide donors including amyl nitrate, nitroglycerine, nitroprussiate, nitrosothioles and nicorandyl, of the compounds that increase the level of cyclic GMP in the penile tissue and of other compounds used to facilitate penile erection in man.

  本发明是指利用通式(I)的 2,5-二羟基苯磺酸的衍生物，开发具有治疗价值的药 品，以增强磷酸二酯酶-5 的作用，包括西地那非、伐地那非和 IC-351、阿朴吗啡、一氧化氮供体（包括硝酸戊酯、硝化甘油、硝普赛特、亚硝基硫醇和烟酰）、增加阴茎组织中环状 GMP 水平的化合物以及其他用于促进男性阴茎勃起的化合物。
• Phamaceutical composition comprising a 2,5-dihydroxybenzenesulfonic-compound, a potassium ion channel modulator and a phosphodiesterase type 5 inhibitor
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1676573A1

  公开（公告）日：2006-07-05

  The present invention relates to a pharmaceutical composition comprising a 2,5-dihydroxybenzenesulfonic compound, a potassium ion channel modulator and a phosphodiesterase type 5 inhibitor, a medicament comprising said pharmaceutical composition as well as the use of said pharmaceutical composition for the manufacture of a medicament.

  本发明涉及一种由 2,5-二羟基苯磺酸化合物、钾离子通道调节剂和 5 型磷酸二酯酶抑制剂组成的药物组合物，一种包含所述药物组合物的药品，以及使用所述药物组合物制造药品。
• Use of derivatives of 2, 5-dihydroxybenzenesulphonic acid derivatives in the production of a medication used to potentiate the effect of other drugs in the treatment of erectile dysfunction
  申请人：——

  公开号：US20040143010A1

  公开（公告）日：2004-07-22

  The present invention refers to the use of derivatives of 2,5-dihidroxybenzenosulphonic acids of general formula (I), to develop medicinal products of therapeutic value to enhance the effects of phosphodiesterase-5 including sildenaphyl, vardenaphyl and IC-351, of apomorphine, of nitric oxide donors including amyl nitrate, nitroglycerine, nitroprussiate, nitrosothioles and nicorandyl, of the compounds that increase the level of cyclic GMP in the penile tissue and of other compounds used to facilitate penile erection in man. 1

  本发明是指利用通式(I)的 2,5-二羟基苯磺酸的衍生物，开发具有治疗价值的药 品，以增强磷酸二酯酶-5 的作用，包括西地那非、伐地那非和 IC-351、阿朴吗啡、一氧化氮供体（包括硝酸戊酯、硝化甘油、硝普赛特、亚硝基硫醇和烟酰）、能提高阴茎组织中环状 GMP 水平的化合物以及用于促进男性阴茎勃起的其他化合物。 1
• Use of 2,5-dihydroxybenzenesulfonic compounds for the treatment of disorders based on an impairment of no production and/or of regulation of edhf function
  申请人：Esteve-Soler Jose

  公开号：US20060135611A1

  公开（公告）日：2006-06-22

  The present invention relates to the use of 2,5-dihydroxybenzenesulfonic compounds for the manufacture of a medicament for the regulation of nitric oxide (NO) synthesis and/or the regulation of EDHF (Endothelium-Derived-Hyperpolarizing-Factor) in the endothelium of diabetic patients, whereby the medicament is administered in a daily dose of the 2,5-dihydroxybenzenesulfonic compounds of formula (I) of <500 mg.

  本发明涉及 2,5-二羟基苯磺酸化合物用于制造一种调节糖尿病患者血管内皮中一氧化氮（NO）合成和/或 EDHF（内皮源性超极化因子）的药物，其中药物的每日给药剂量为式（I）的 2,5-二羟基苯磺酸化合物小于 500 毫克。
• DERIVES 2,5-DIHYDROXYBENZENESULFONIQUES POUR LE TRAITEMENT DE LA DYSFONCTION SEXUELLE
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP0954298B1

  公开（公告）日：2006-03-08