N-Isopropyl-6-methyl-2-heptylamine hydrochloride | 4013-92-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Isopropyl-6-methyl-2-heptylamine hydrochloride
• 英文别名: 6-methyl-N-propan-2-ylheptan-2-amine;hydrochloride
• CAS: 4013-92-7
• 化学式: C11H26ClN
• 分子量: 207.78
• InChiKey: QYEORIIWGAAORG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.82
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  16.6
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Terpene amino alcohols and medicinal uses thereof
  申请人：KURARAY CO., LTD.

  公开号：EP0209158A2

  公开（公告）日：1987-01-21

  Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.

  本研究提供了具有抗过敏活性或改善脑功能活性的新型萜烯氨基醇。此外，还提供了这些醇的医疗用途。
• CRYSTALLINE CONDITION DISLOCATING METHOD
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0665009A1

  公开（公告）日：1995-08-02

  An object of this invention is to provide a method of dislocating the crystalline condition of crystalline medicine simply, speedily and homogeneously, and, moreover, in large quantities at once. This invention is directed to a method using an extruder when crystalline medicine in a certain crystalline condition (△ is dislocated to another crystalline condition (○), i.e., when the dislocation of crystalline condition (△->○) is carried out.

  本发明的目的是提供一种简单、快速和均匀地将结晶药物的结晶状态变位的方法，而且是一次性大量变位。本发明针对的是一种使用挤压机将某种结晶状态（△）的结晶药物变位到另一种结晶状态（○）的方法，即结晶状态（△->○）变位的方法。
• FELBINAC-CONTAINING PATCH
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP0968712A1

  公开（公告）日：2000-01-05

  A patch which comprises 10 to 40 wt.% of a styrene/isoprene/styrene block copolymer, 5 to 30 wt.% of a rosin-base resin, 20 to 70 wt.% of a plasticizer, and 1.1 to 10 wt.% of felbinac serving as the active ingredient, does not contain crotamiton serving as the solubilizing agent for felbinac, and has a thickness of 50 to 300 µm.

  由 10 至 40 重量百分比的苯乙烯/异戊二烯/苯乙烯嵌段共聚物、5 至 30 重量百分比的松香基树脂、20 至 70 重量百分比的增塑剂和 1.1 至 10 重量百分比的活性成分非比萘酸组成的贴片，不含作为非比萘酸增溶剂的克罗米通，厚度为 50 至 300 微米。
• SACCHARIDE-CONTAINING COMPOSITIONS
  申请人：FUJI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1008353A1

  公开（公告）日：2000-06-14

  Spray-dried powders containing calcium hydrogen phosphate and saccharides having excellent powder-fluidity and compression-moldability, being quickly disintegrated/dissolved when put into the oral cavity or water in the form of granules, tablets, etc., being useful as fillers, compression-moldability improvers, disintegration aids, administration-facilitating agents, solubilizers in the oral cavity, etc. and being applicable to drugs, foods, etc.

  含有磷酸氢钙和糖类的喷雾干燥粉末，具有极佳的粉末流动性和压模性，以颗粒、片剂等形式放入口腔或水中时可迅速崩解/溶解，可用作填充剂、压模性改进剂、崩解辅助剂、给药促进剂、口腔增溶剂等，适用于药物、食品等。
• Felbinac-containing patch
  申请人：HISAMITSU PHARMACEUTICAL CO., INC.

  公开号：EP1072261A2

  公开（公告）日：2001-01-31

  There is provided a felbinac-containing patch that stably produces a sufficient anti-inflammatory, analgesic effect by felbinac exhibiting a strong anti-inflammatory, analgesic action without bringing harmful effects such as skin irritation over a long period and, at the same time, that is excellent in the stability of preparations as well as in their adhesive properties, the felbinac-containing patch comprising 10-30 wt% of a styrene-isoprene-styrene block copolymer, 5-15 wt% of polyisobutylene, 5-30 wt% of a rosin-based resin, 30-70 wt% of a plasticizer, 1-5 wt% of felbinac, and 0.01-5 wt% of a dispersing agent,    wherein the drug release rate of the patch at one hour after the start of the water-release test using a rotating cylinder described in the release test method as prescribed in United State Pharmacopoeia is 20±15 wt%, the drug release rate of the patch at three hours after the start of test is 40±15 wt%, and the drug release rate of the patch at six hours after the start of test is 60±20 wt%.

  本发明提供了一种含有非比萘酸的贴片，该贴片通过非比萘酸表现出强烈的消炎镇痛作用，可长期稳定地产生足够的消炎镇痛效果，且不会带来有害影响，如皮肤刺激、含有非比萘酸的贴片由 10-30 wt%的苯乙烯-异戊二烯-苯乙烯嵌段共聚物、5-15 wt%的聚异丁烯、5-30 wt%的松香基树脂、30-70 wt%的增塑剂、1-5 wt%的非比萘酸和 0.01-5 wt% 的分散剂、 其中，使用《美国药典》规定的释放试验方法中所述的旋转圆筒进行释放水试验，试验开始后一小时，贴片的药物释放率为20±15 wt%，试验开始后三小时，贴片的药物释放率为40±15 wt%，试验开始后六小时，贴片的药物释放率为60±20 wt%。