2-Azaniumylethylazanium;diiodide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Azaniumylethylazanium;diiodide
• 英文别名: 2-azaniumylethylazanium;diiodide
• 化学式: C2H10I2N2
• 分子量: 315.92
• InChiKey: IWNWLPUNKAYUAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.14
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  4
• 氢受体数：
  2

ADMET

毒理性

• 副作用

皮肤致敏剂 - 一种可以诱导皮肤产生过敏反应的制剂。

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

兽医：对于碘中毒没有解毒剂。必须消除碘的来源。然后临床征状可能在几天内减轻。如果存在感染，则需要进行常规治疗，但预后谨慎。

VET: THERE IS NO ANTIDOTE FOR IODISM. SOURCE OF IODINE MUST BE ELIMINATED. CLINICAL SIGNS MAY THEN ABATE IN A FEW DAYS. IF INFECTION IS PRESENT, CONVENTIONAL THERAPY IS WARRANTED BUT PROGNOSIS IS GUARDED.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

过量摄入EDDI会导致牛出现咳嗽、浆液性鼻涕、流泪、精神沉郁或不愿移动、呼吸沉重和轻微发热的症状... 羊也会表现出类似的症状... 如果从饲料中移除EDDI，这些症状会在几天内减轻。

EXCESS EDDI CAUSES CATTLE TO MANIFEST COUGHING, SEROMUCOUS NASAL DISCHARGE, LACRIMATION, DULLNESS OR RELUCTANCE TO MOVE, HEAVY BREATHING, & SLIGHT FEVER... SHEEP MANIFEST SIMILAR SIGNS... THESE SIGNS ABATE WITHIN A FEW DAYS IF EDDI...REMOVED FROM RATION.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

牛可能会对经过EDDI处理的矿物质补充剂产生喜好，并且通过每天每头动物吃下1磅或更多的量而导致过量摄入。与无机碘化物不同，EDDI对胃肠粘膜没有刺激性。

CATTLE CAN DEVELOP TASTE FOR EDDI-TREATED MINERAL SUPPLEMENTS & OVERDOSE THEMSELVES BY EATING 1 LB OR MORE/ANIMAL/DAY. UNLIKE INORG IODIDES, EDDI IS NOT IRRITATING TO GI LININGS.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

如果群体中存在疾病问题，或者动物处于压力之下，临床症状会恶化。动物可能会停止进食，并出现105-108华氏度的高烧。可能会发生支气管肺炎或败血症...

IF THERE IS DISEASE PROBLEM IN HERD OR IF ANIMALS ARE STRESSED, CLINICAL SIGNS...WORSENED. ANIMALS MAY GO OFF FEED...DEVELOP FEVER OF 105-108 °F. BRONCHOPNEUMONIA OR SEPTICEMIA CAN OCCUR...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在牛身上，正常的总血清碘浓度范围从5.6到14微克/100毫升...在羊身上，正常的总血清碘浓度约为2.3-4.6微克/100毫升...在EDDI诱导的碘病和感染的情况下...总血清碘浓度.../报告/是正常值的10-100倍或更多。

IN CATTLE NORMAL TOTAL SERUM IODINE CONCN RANGES FROM 5.6 TO 14 UG/100 ML... IN SHEEP NORMAL TOTAL SERUM IODINE CONCN IS ABOUT 2.3-4.6 UG/100 ML... IN CASES OF EDDI-INDUCED IODISM &...INFECTION...TOTAL SERUM IODINE CONCN.../REPORTED/ 10-100 OR MORE TIMES NORMAL.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

碘化物很容易通过牛奶排出/牛的/. ... 碘化物...也由呼吸道腺体细胞分泌...唾液和泪腺也分泌碘化物。

IODIDES ARE READILY EXCRETED IN MILK /OF CATTLE/. ... IODIDES...ALSO SECRETED BY GLANDULAR CELLS IN RESP TRACT... SALIVARY & LACRIMAL GLANDS ALSO SECRETE IODIDES.

来源:Hazardous Substances Data Bank (HSDB)