1,10-Diaminodecane dihydrochloride | 7408-92-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,10-Diaminodecane dihydrochloride
• 英文别名: decane-1,10-diamine;dihydrochloride
• CAS: 7408-92-6
• 化学式: C10H26Cl2N2
• 分子量: 245.23
• InChiKey: DFHIFRBDQIFRFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.4
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] PROCESS OF PREPARING POLYMERIC NANOPARTICLES THAT CHELATE RADIOACTIVE ISOTOPES AND HAVE A SURFACE MODIFIED WITH SPECIFIC MOLECULES TARGETING THE PSMA RECEPTOR AND THEIR USE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE NANOPARTICULES POLYMÈRES QUI CHÉLATENT DES ISOTOPES RADIOACTIFS ET DONT UNE SURFACE EST MODIFIÉE PAR DES MOLÉCULES SPÉCIFIQUES CIBLANT LE RÉCEPTEUR DU PSMA ET LEUR UTILISATION
  申请人：NANOTHEA S A

  公开号：WO2020188318A1

  公开（公告）日：2020-09-24

  Process for preparation of polymeric nanoparticles that chelate radioactive isotopes and have their surface modified with specific molecules targeting PSMA receptor on the surface of cancer cells, with a targeting agent modified by a linker molecule attaching to free aldehyde groups present in the dextran chain. Polymeric nanoparticles that chelate radioactive isotopes synthesised according to the claimed process for use in therapy and diagnostics of prostate cancer and metastatic cancer cells as well as other affected cells for which the nanoparticles show the affinity.

  制备聚合物纳米粒子的过程，这些纳米粒子与放射性同位素螯合，并且它们的表面被特定分子修饰，以针对癌细胞表面的PSMA受体，通过连接分子修饰的靶向剂连接到右旋糖酐链上存在的游离醛基。根据所述方法合成的螯合放射性同位素的聚合物纳米粒子，用于前列腺癌和转移性癌细胞以及其他纳米粒子显示亲和性的受影响细胞的治疗和诊断。
• [EN] DIMERS OF BIGUANIDINES AND THEIR THERAPEUTIC USES<br/>[FR] DIMÈRES DE BIGUANIDINES ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：INST CURIE

  公开号：WO2022106505A1

  公开（公告）日：2022-05-27

  The present invention relates to compounds comprising two biguanidyl radicals that can be useful as anti-inflammatory agent, and also to new compounds comprising two biguanidyl radicals and their use as a drug, in particular for treating a cancer, a metabolic disease, a secondary mitochondrial disorder due to copper overload including Indian childhood cirrhosis, Wilson's disease and Idiopathic infantile copper toxicosis or due to iron overload, an infection by a virus such as a coronavirus or an influenza virus, a neurodegenerative disease or disorder and aging.

  本发明涉及包含两个双胍基基团的化合物，可用作抗炎剂，并且涉及包含两个双胍基基团的新化合物及其用途作为药物，特别是用于治疗癌症、代谢性疾病、由铜超载引起的继发性线粒体疾病，包括印度儿童肝硬化、威尔逊氏病和特发性婴儿铜中毒或由铁超载引起的感染病毒，如冠状病毒或流感病毒，神经退行性疾病或障碍和衰老。
• PROCESS OF PREPARING POLYMERIC NANOPARTICLES THAT CHELATE RADIOACTIVE ISOTOPES AND HAVE A SURFACE MODIFIED WITH SPECIFIC MOLECULES TARGETING THE PSMA RECEPTOR AND THEIR USE
  申请人：Nanothea S.A.

  公开号：EP3941534A1

  公开（公告）日：2022-01-26
• [EN] METHOD FOR PREPARING POLYALKYLENEBIGUANIDINE SALT<br/>[FR] PROCEDE DE PREPARATION DE SEL DE POLYALKYLENE-BIGUANIDINE
  申请人：SK CHEMICALS CO LTD

  公开号：WO2005016994A1

  公开（公告）日：2005-02-24

  A method for preparing polyalkylenebiguanidine salt, which does not require a high-viscosity reactor and a toxic solvent, and is capable of producing various polyalkylenebiguanidine salt, is disclosed. The method comprises the steps of: polymerizing alkylenediamine dihydrochloride and dicyanamide metal salt in the presence of solvent or without solvent; neutralizing the polymerization product by adding water, and alkali metal compound or alkaline earth metal compound into the polymerization product; separating a neutralized polyalkylenebiguanidine polymer layer from an aqueous layer after inducing a phase-separation by settling the neutralized polymerization product; and adding acid into the separated polyalkylenebiguanidine polymer layer. Alternatively, the polyalkylenebiguanidine salt can be prepared by the method comprising the steps of: polymerizing alkylenediamine dihydrochloride and dicyanamide metal salt in the presence of solvent; and removing solvent and byproduct from the obtained polymerization product.