N-Butyl-noradrenalin | 1951-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-Butyl-noradrenalin
• 英文别名: N-n-Butylnoradrenalin；(+/-)-Butylnoradrenaline；2-butylamino-1-(3,4-dihydroxy-phenyl)-ethanol；2-Butylamino-1-(3,4-dihydroxy-phenyl)-aethanol；3,4-Dihydroxy-alpha-(butylaminomethyl)benzyl alcohol；4-[2-(butylamino)-1-hydroxyethyl]benzene-1,2-diol
• CAS: 1951-20-8
• 化学式: C₁₂H₁₉NO₃
• 分子量: 225.288
• InChiKey: ZCIITWDRVZDHDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 水 、 钯 作用下， 生成 N-Butyl-noradrenalin
  参考文献：
  名称：

  Preparation of N-Substituted 1-(3′,4′-Dihydroxyphenyl)-2-aminoethanols

  摘要：

  DOI：

  10.1021/ja01170a044

文献信息

• Respiratory Drug Condensation Aerosols and Methods of Making and Using Them
  申请人：Hale Ron L.

  公开号：US20090258075A1

  公开（公告）日：2009-10-15

  Described herein are respiratory drug condensation aerosols and methods of making and using them. Kits for delivering condensation aerosols are also described. The respiratory drug aerosols typically comprise respiratory drug condensation aerosol particles. In some variations the respiratory drug compound is selected from the group consisting of β-adrenergics, methylxanthines, anticholinergics, corticosteroids, mediator-release inhibitors, anti-leukotriene drugs, asthma inhibitors, asthma antagonists, anti-endothelin drugs, prostacyclin drugs, ion channel or pump inhibitors, enhancers, or modulators and pharmaceutically acceptable analogs, derivatives, and mixtures thereof. Methods of treating a respiratory ailment using the described aerosols are also described. In general, the methods typically comprise the step of administering a therapeutically effective amount of respiratory drug condensation aerosol to a person with a respiratory ailment. Methods of forming a respiratory drug condensation aerosol are also described. The methods comprise the steps of vaporizing and condensing a respiratory drug composition.
• US4244967A
  申请人：——

  公开号：US4244967A

  公开（公告）日：1981-01-13
• US5047592A
  申请人：——

  公开号：US5047592A

  公开（公告）日：1991-09-10
• US8506935B2
  申请人：——

  公开号：US8506935B2

  公开（公告）日：2013-08-13
• US9964552B2
  申请人：——

  公开号：US9964552B2

  公开（公告）日：2018-05-08