3-cyano-α-[(dimethylamino)methylene]-5,7-bis(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-acetonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 3-cyano-α-[(dimethylamino)methylene]-5,7-bis(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-acetonitrile
• 英文别名: 2-[(1Z)-1-cyano-2-(dimethylamino)eth-1-en-1-yl]-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile；2-[(Z)-1-cyano-2-(dimethylamino)ethenyl]-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
• 化学式: C₁₄H₈F₆N₆
• 分子量: 374.248
• InChiKey: PRIYATJMSDYILD-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• Compounds
  申请人：——

  公开号：US20030134862A1

  公开（公告）日：2003-07-17

  The present invention relates to novel compounds which are pyrazolo[1,5-a]pyrimidines, and which modulate the activity of peroxisome proliferator-activated receptors (PPAR) &agr; and/or &ggr;. The said compounds are predicted to be useful in the treatment of metabolic diseases, e.g. type II diabetes.

  本发明涉及新型化合物，它们是吡唑并［1,5-a］嘧啶，并且调节过氧化物酶体增殖物激活受体（PPAR）α和/或γ的活性。这些化合物被预测可用于治疗代谢性疾病，例如2型糖尿病。
• [EN] PIPAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AS MODULATORS OF PPAR<br/>[FR] DERIVES DE PYRAZOLO[1,5-A] PYRIMIDINE UTILISES COMME MODULATEURS DE PPAR
  申请人：BIOVITRUM AB

  公开号：WO2003053976A1

  公开（公告）日：2003-07-03

  The present invention relates to novel compounds which are pyrazolo[1,5-a] pyrimidines, and which modulate the activity of peroxisome proliferator-activited receptors (PPAR) α and/or Ϝ. The said compounds are predicted to be useful in the treatment of metabolic diseases, e.g. type II diabetes. Or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, C1-6 alkylthio, arylalkylthio, cyano-C1-6 alkyl, -C(CN)=CH-R1 or -CH(CN)-CH2-R1,