3-Quinuclidinyl phenylcyclopentylglycolate | 26758-53-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: 3-Quinuclidinyl phenylcyclopentylglycolate
• 英文别名: 1-azabicyclo[2.2.2]octan-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate
• CAS: 26758-53-2
• 化学式: C₂₀H₂₇NO₃
• 分子量: 329.4
• InChiKey: RFXCNPOWSCFJCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compounds, Compositions and Methods for Treatment of Myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US20200247760A1

  公开（公告）日：2020-08-06

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-甲基酯和酰胺化合物及其组合物。本文还提供了一种预防或延迟需要该治疗的患者近视发生的方法，包括向该患者施用本文提供的化合物或组合物。本文还提供了一种减缓或预防需要该治疗的患者近视进展的方法，包括向该患者施用本文提供的化合物或组合物。
• Compounds, compositions and methods for treatment of myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US11117869B2

  公开（公告）日：2021-09-14

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-基甲烷酯和酰胺化合物及组合物。本文还提供了预防或延迟有需要的受试者近视发生的方法，包括向受试者施用本文提供的化合物或组合物。本文还提供了减少或预防有需要的受试者近视发展的方法，包括对受试者施用本文提供的化合物或组合物。
• Methods of treating or preventing preterm labor
  申请人：Visco Anthony G.

  公开号：US11179393B2

  公开（公告）日：2021-11-23

  Described herein are methods for treating preterm labor, stopping labor prior to Cesarean delivery, preventing preterm labor, or controlling the timing of parturition by administering a chemical compound, such as a muscarinic receptor antagonist preferably a M, receptor antagonist, or a β-3 adrenergic agonist. Also described are methods for treating preterm labor, stopping labor preparatory to Cesarean delivers', preventing preterm labor, or controlling the timing of parturition by administering an effective amount of transdermal stimulation, posterior tibial nerve stimulation or another form of non-invasive or invasive neuromodulation, unstimulated or stimulated acupuncture, magnetic field therapy, or vibratory stimulation. These methods may be practiced individually, in combination with each other, or in combination with known tocolytic methods or medications.

  本文描述了通过施用化合物，如毒蕈碱受体拮抗剂，优选M受体拮抗剂或β-3肾上腺素能激动剂，治疗早产、停止剖宫产前的分娩、预防早产或控制分娩时间的方法。还描述了通过给予有效量的经皮刺激、胫后神经刺激或另一种形式的非侵入性或侵入性神经调节、非刺激或刺激性针灸、磁场疗法或振动刺激来治疗早产、停止剖宫产前的准备性分娩、预防早产或控制分娩时间的方法。这些方法可以单独使用，也可以相互结合使用，或与已知的溶血方法或药物结合使用。
• METHODS OF TREATING OR PREVENTING PRETERM LABOR
  申请人：Visco, Anthony G.

  公开号：EP3139924A1

  公开（公告）日：2017-03-15
• US6482837B1
  申请人：——

  公开号：US6482837B1

  公开（公告）日：2002-11-19