7-{7-methyl-5-[(3S)-tetrahydrofuran-3-yl]imidazo[5,1-f][1,2,4]triazin-4-yl}-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,7-naphthyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-{7-methyl-5-[(3S)-tetrahydrofuran-3-yl]imidazo[5,1-f][1,2,4]triazin-4-yl}-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,7-naphthyridine
• 英文别名: 7-[7-methyl-5-[(3S)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazin-4-yl]-2-(trifluoromethyl)-6,8-dihydro-5H-1,7-naphthyridine
• 化学式: C₁₉H₁₉F₃N₆O
• 分子量: 404.395
• InChiKey: MYZJFYUDILCCEH-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  68.4
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Triazine Derivatives
  申请人：Pfizer Inc.

  公开号：US20140329820A1

  公开（公告）日：2014-11-06

  The present invention is directed to a new class of triazine derivatives as described by formula I below in which A, X, R 1 , R 2 , R 3 , and R 4 are as defined herein and to the use of the compounds as PDE10 inhibitors.

  本发明涉及一种新的三嗪衍生物类别，如下式所示，其中A、X、R1、R2、R3和R4如本文所定义，并且涉及将这些化合物用作PDE10抑制剂。
• IMIDAZO-TRIAZINE DERIVATIVES AS PDE10 INHIBITORS
  申请人：Pfizer Inc.

  公开号：EP2991989B1

  公开（公告）日：2017-06-28
• US9145427B2
  申请人：——

  公开号：US9145427B2

  公开（公告）日：2015-09-29
• US9296761B2
  申请人：——

  公开号：US9296761B2

  公开（公告）日：2016-03-29
• [EN] IMIDAZO-TRIAZINE DERIVATIVES AS PDE10 INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZO-TRIAZINE UTILISÉS COMME INHIBITEURS DE LA PDE10
  申请人：PFIZER

  公开号：WO2014177977A1

  公开（公告）日：2014-11-06

  The present invention is directed to a new class of triazine derivatives as described by formula (I) below in which A, X, R1, R2, R3, and R4 are as defined herein and to the use of the compounds as PDE10 inhibitors.