Benzo(b)thiophene, dimethyl- | 30027-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: Benzo(b)thiophene, dimethyl-
• 英文别名: 3,4-dimethyl-1-benzothiophene
• CAS: 30027-44-2
• 化学式: C₁₀H₁₀S
• 分子量: 162.25
• InChiKey: JJKNUCHFWIZBIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PYRIDINE DERIVATIVE
  申请人：TEIJIN PHARMA LIMITED

  公开号：US20150284358A1

  公开（公告）日：2015-10-08

  Provided is a pyridine derivative represented by formula (I), a prodrug thereof, a pharmaceutically acceptable salt of the pyridine derivative or the prodrug, or a solvate of the pyridine derivative, the prodrug or the pharmaceutically acceptable salt, which is useful for treatment or prophylaxis of diseases associated with URAT1 such as gout, hyperuricemia, hypertension, kidney diseases such as interstitial nephritis, diabetes, arteriosclerosis and Lesch-Nyhan syndrome.

  提供的是由化学式（I）表示的吡啶衍生物，其前药，吡啶衍生物或前药的药用可接受盐，或者吡啶衍生物，前药或药用可接受盐的溶剂，用于治疗或预防与URAT1相关的疾病，如痛风，高尿酸血症，高血压，肾脏疾病如间质性肾炎，糖尿病，动脉硬化和Lesch-Nyhan综合征。
• [EN] HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORDERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE.<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES POUR LE TRAITEMENT OU LA PRÉVENTION DE TROUBLES PROVOQUÉS PAR UNE NEUROTRANSMISSION RÉDUITE DE LA SÉROTONINE, DE LA NORÉPINEPHRINE OU DE LA DOPAMINE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2012036253A1

  公开（公告）日：2012-03-22

  A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents -O- or -CH2-; R1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R2 and R3, which are the same or different, each independently represent hydrogen or a lower alkyl group; or R2 and R3 are bonded to form a cyclo-C3-C8 alkyl group; and R4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).

  通用式（1）表示的杂环化合物或其盐：其中m、l和n分别表示1或2的整数；X表示-O-或-CH2-；R1表示氢、较低的烷基基团、羟基较低的烷基基团、保护基或三较低烷氧基较低的烷基基团；R2和R3，相同或不同，各自独立地表示氢或较低的烷基基团；或R2和R3结合形成环-C3-C8烷基基团；R4表示芳香基团或杂环基团，其中芳香基团或杂环基团可能具有一个或多个任意取代基。
• [EN] AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS<br/>[FR] THIAZOLES À SUBSTITUTION AMIDE UTILISÉS EN TANT QU'INHIBITEURS DE LA SÉCRÉTINE PROTÉIQUE
  申请人：KEZAR LIFE SCIENCES

  公开号：WO2019046668A1

  公开（公告）日：2019-03-07

  Provided herein are thiazole carboxamide protein secretin inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

  本文提供了噻唑羧酰胺蛋白质分泌抑制剂，例如Sec61的抑制剂，其制备方法，相关的药物组合物，以及使用这些物质的方法。例如，本文提供了化合物的公式（I）：及其药用盐和包含这些化合物的组合物。本文披露的化合物可以用于治疗炎症和/或癌症等疾病。
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：US20190326526A1

  公开（公告）日：2019-10-24

  An organometallic compound represented by Formula 1, an organic light-emitting device including the organometallic compound, and a diagnostic composition including the organometallic compound. wherein, in Formula 1, R 1 to R 12 and R 19 are the same as described in the specification.

  由公式1表示的有机金属化合物，包括该有机金属化合物的有机发光器件，以及包括该有机金属化合物的诊断组合物。在公式1中，R1至R12和R19与规范中描述的相同。
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：US20200071346A1

  公开（公告）日：2020-03-05

  An organometallic compound represented by Formula 1, an organic light-emitting device including the same, and a diagnostic composition including the organometallic compound: wherein, Formula 1, R 1 to R 12 and R 21 to R 23 are each independently the same as described in the detailed description of the specification.

  一种由化学式1表示的有机金属化合物，包括该化合物的有机发光器件，以及包括该有机金属化合物的诊断组合物：其中，化学式1中，R1至R12和R21至R23分别独立地与专利说明书中所描述的相同。