3-Chloro-4-fluoro-5-nitrophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-Chloro-4-fluoro-5-nitrophenol
• 英文别名: 3-chloro-4-fluoro-5-nitrophenol
• 化学式: C6H3ClFNO3
• 分子量: 191.54
• InChiKey: IEMSQRYDECBNOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES<br/>[FR] BENZIMIDAZOLES POUR UNE UTILISATION DANS LE TRAITEMENT DU CANCER ET DES MALADIES INFLAMMATOIRES
  申请人：CAPELLA THERAPEUTICS INC

  公开号：WO2017053537A1

  公开（公告）日：2017-03-30

  Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

  本文提供了使用苯并咪唑类化合物治疗、预防或改善由脂质激酶或蛋白激酶介导的疾病、紊乱或症状的方法，例如公式I或II的苯并咪唑类化合物及其药物组合物。本文还提供了苯并咪唑类化合物及其药物组合物，以及它们用于治疗、预防或改善增生性疾病症状的方法。
• Benzimidazoles for use in the treatment of cancer and inflammatory diseases
  申请人：CAPELLA THERAPEUTICS, INC.

  公开号：US10590108B2

  公开（公告）日：2020-03-17

  Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

  本文提供了用苯并咪唑（例如，式I或式II）治疗、预防或改善由脂质激酶或蛋白激酶介导的病症、紊乱或疾病的一种或多种症状的方法及其药物组合物。本文还提供了苯并咪唑及其药物组合物，以及使用它们治疗、预防或改善增殖性疾病的一种或多种症状的方法。
• BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES
  申请人：CAPELLA THERAPEUTICS, INC.

  公开号：US20180273511A1

  公开（公告）日：2018-09-27

  Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.