申请人:Grimmond Brian James
公开号:US20110243858A1
公开(公告)日:2011-10-06
A method of diagnostic imaging is disclosed comprising administering a medical formulation to a subject, the formulation comprising a contrast enhancement agent having structure I and salts thereof
wherein R
1
is independently at each occurrence a hydroxy group, a C
1
-C
3
hydroxyalkyl group, or a C
1
-C
3
alkyl group, and b is 0-4; R
2
-R
7
are independently at each occurrence hydrogen, a C
1
-C
3
hydroxyalkyl group, or a C
1
-C
3
alkyl group, with the proviso that at least one of R
1
-R
7
is a hydroxy group or a C
1
-C
3
hydroxyalkyl group; and wherein Q is one or more charge balancing counterions; and one or more pharmaceutically acceptable carriers and excipients. The subject is subjected to a diagnostic imaging technique such as magnetic resonance imaging. The technique may be used in a variety of diagnostic imaging regimes, such as imaging of circulatory systems, genitourinary systems, hepatobiliary systems, central nervous systems, tumors, and abscesses among others.
揭示了一种诊断成像方法,包括向受试者注射医用配方,该配方包括具有结构I和其盐的对比增强剂,其中R1在每次出现时独立地是羟基、C1-C3羟基烷基或C1-C3烷基,b为0-4;R2-R7在每次出现时独立地是氢、C1-C3羟基烷基或C1-C3烷基,但至少其中之一是羟基或C1-C3羟基烷基;Q是一个或多个电荷平衡的对离子;以及一个或多个药用载体和赋形剂。受试者接受诊断成像技术,如磁共振成像。该技术可用于各种诊断成像方案,如循环系统、泌尿系统、肝胆系统、中枢神经系统、肿瘤和脓肿等的成像。