Norethindrone acetate and ethinyl estradiol | 8015-12-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Norethindrone acetate and ethinyl estradiol
• 英文别名: (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;[(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
• CAS: 8015-12-1
• 化学式: C42H52O5
• 分子量: 636.9
• InChiKey: GEONECATAKDDLT-JDSZYESASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.68
• 重原子数：
  47
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA
  申请人：Pharmacia Corporation

  公开号：EP1363669A2

  公开（公告）日：2003-11-26
• METHOD AND APPARATUS FOR PACKAGING AND DISPENSING PHARMACEUTICALS
  申请人：Tramonte Arturo

  公开号：US20110240504A1

  公开（公告）日：2011-10-06

  A method of packaging one or more pharmaceuticals comprising separating a plurality of unit doses into a plurality of unit dose compartments, wherein each unit dose compartment of the plurality of unit dose compartments holds only one unit dose of the plurality of unit doses, each unit dose having the same strength, wherein the plurality of unit doses is precisely a quantity equal to a most commonly prescribed number of unit doses in individual prescriptions for the unit dose, or a multiple thereof is provided. Also provided are kits prepared by the method. Methods for designing such kits and packaging are also provided.
• [EN] TRANSDERMAL DELIVERY SYSTEM USING A COMBINATION OF PERMEATION ENHANCERS<br/>[FR] SYSTEME D'APPORT TRANSCUTANE UTILISANT UNE COMBINAISON DE SUBSTANCES FAVORISANT LA PENETRATION
  申请人：CYGNUS THERAPEUTIC SYSTEMS

  公开号：WO1995005137A1

  公开（公告）日：1995-02-23

  (EN) Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered steroid drugs. The composition contains benzyl alcohol, propylene glycol monolaurate and a C2-C6 alkanediol. The compositions are particularly useful in conjunction with the transdermal administration of progestogens and estrogens. Methods and drug delivery systems for using the enhancer compositions are provided as well.(FR) Compositions favorisant la pénétration à travers la peau, augmentant la perméabilité de la peau pour des médicaments stéroïdiques à administration transcutanée. Lesdites compositions comprennent de l'alcool benzylique, du monolaurate de propylène glycol et un alcanediol C2-C6. Elles sont particulièrement utiles en conjonction avec l'administration transdermique de progestatif et d'oestrogènes. Des procédés et des systèmes d'apport de médicaments reposant sur l'utilisation desdites compositions favorisant la pénétration sont également décrits.
• [EN] METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA<br/>[FR] METHODE D'UTILISATION D'UN INHIBITEUR DE LA CYCLOOXYGENASE-2 ET DE STEROIDES SEXUELS DANS UNE POLYTHERAPIE POUR TRAITER ET PREVENIR LA DYSMENORRHEE
  申请人：PHARMACIA CORP

  公开号：WO2002062391A2

  公开（公告）日：2002-08-15

  The present invention provides methods for the treatment and prevention of dysmenorrhea in a woman using a combination of a cyclooxygenase-2 inhibitor and sex steroids.