[4-[[4-(Diethylamino)phenyl]-[6-[dihydroxy(oxo)-lambda6-sulfanylidene]-3-oxo-4-sulfocyclohexa-1,4-dien-1-yl]methylidene]cyclohexa-2,5-dien-1-ylidene]-diethylazanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [4-[[4-(Diethylamino)phenyl]-[6-[dihydroxy(oxo)-lambda6-sulfanylidene]-3-oxo-4-sulfocyclohexa-1,4-dien-1-yl]methylidene]cyclohexa-2,5-dien-1-ylidene]-diethylazanium
• 英文别名: [4-[[4-(diethylamino)phenyl]-[6-[dihydroxy(oxo)-λ6-sulfanylidene]-3-oxo-4-sulfocyclohexa-1,4-dien-1-yl]methylidene]cyclohexa-2,5-dien-1-ylidene]-diethylazanium
• 化学式: C27H33N2O7S2+
• 分子量: 561.7
• InChiKey: DHAHKSQXIXFZJB-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  152
• 氢给体数：
  3
• 氢受体数：
  8

ADMET

代谢

体外研究已经显示，专利蓝不会被代谢。

In vitro studies have shown that patent blue is not metabolized.

来源:DrugBank

毒理性

• 蛋白质结合

专利蓝特异性地与白蛋白结合，这使得它能够通过乳腺淋巴管传播。

Patent blue gets specifically bound to albumin which allows it to travel through the breast lymphatics.

来源:DrugBank

吸收、分配和排泄

• 吸收

专利蓝在淋巴系统中被选择性吸收。当口服给药时，专利蓝的吸收非常低，并且系统可用性有限。

Patent blue is selectively absorbed in the lymphatics. When administered orally, patent blue has a very low absorption and limited systemic availability.

来源:DrugBank

吸收、分配和排泄

• 消除途径

专利蓝被排泄到尿液和胆汁中。在尿液中的排泄更为显著，甚至在静脉注射专利蓝后，尿液可能会变成蓝色。当口服给药时，专利蓝以未改变的形式在粪便中排泄。

Patent blue is excreted into the urine and bile.The excretion is more significant in the urine which after the administration of patent blue intravenously can even change to a blue coloration. When administered orally, patent blue is excreted unchanged in feces.

来源:DrugBank

吸收、分配和排泄

• 分布容积

这个药代动力学参数尚未被研究。

This pharmacokinetic parameter has not been studied.

来源:DrugBank

吸收、分配和排泄

• 清除

这个药代动力学特性尚未被充分研究。

This pharmacokinetic property has nos been fully studied.

来源:DrugBank

文献信息

• CHROMOGENIC PEROXIDASE SUBSTRATES
  申请人：Dako Denmark A/S

  公开号：US20170175178A1

  公开（公告）日：2017-06-22

  Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.

  描述了用于基于颜色的目标检测的色素结合物。这些结合物包含一个色素部分，例如罗丹明、罗丹醇或荧光素。色素部分与过氧化物酶底物相连。色素结合物可用于免疫组织化学分析和原位杂交。这些结合物可以通过颜色检测样品中的1个、2个、3个或更多目标。
• Cosmetic compositions
  申请人：Symrise AG

  公开号：EP2745878A1

  公开（公告）日：2014-06-25

  Suggested is a cosmetic compositions comprising (a) a crosspolymer obtained from copolymerisation of at least two different polyols and at least one dicarboxylic acid and (b) at least one fragrance.

  建议的是一种化妆品组合物，包括 (a) 由至少两种不同的多元醇和至少一种二羧酸共聚得到的交联聚合物，以及 (b) 至少一种香料。
• PROCESS FOR PREPARATION OF ISOSULFAN BLUE
  申请人：Kovi Ravishanker

  公开号：US20080281127A1

  公开（公告）日：2008-11-13

  A process for the preparation of isosulfan blue (Active Pharmaceutical Ingredient) is provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon mild oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater.

  提供了一种制备异磺蓝（活性药用成分）的方法。还提供了一种制备中间体2-氯苯甲醛-5-磺酸钠盐（式（2））的方法，该中间体用于制备，并提供了一种分离苯甲醛-2,5-二磺酸二钠盐（式（3））的程序。还提供了一种制备异亮氨酸的方法（式（4）），经轻度氧化后可得到药用级别的异磺蓝，可用于制备药物配方。在该过程中提供的分离和纯化程序可提供具有HPLC纯度为99.5%或更高的几乎纯净的异磺蓝。
• Bioluminescent Endoscopy Methods And Compounds
  申请人：Neff Philip T.

  公开号：US20090081129A1

  公开（公告）日：2009-03-26

  Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.

  生物发光内窥镜检查方法和化合物，其中通过注入、灌注、插管、注射或以其他方式给予含有生物发光物质或产生生物发光的琼脂素和琼脂酶混合物的溶液来检查解剖物体，其中使用由生物发光物质发出的生物发光的图像和信息构成物体的彩色或单色图像。演示了允许将生物发光溶液灌注到某些组织区域的程序，例如但不限于常见胆管、泌尿道、胃肠道、心血管系统和淋巴系统，其中这些结构可以在手术过程中方便地可视化，以避免对这些结构造成损伤。这些图像也可以与可见光图像结合。提供了使用生物发光检测癌细胞的方法。公开的首选实施例包括膜渗透性海葵素类似物。
• COLORING AGENTS AND METHODS OF USE THEREOF
  申请人：Living Proof, Inc.

  公开号：US20160106648A1

  公开（公告）日：2016-04-21

  Dyes, compositions comprising dyes and methods for using the same are provided.

  染料、包含染料的组合物以及使用这些染料的方法。