2,6-Dimethyl-4-((E)-2-nitro-vinyl)-phenol | 210057-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-Dimethyl-4-((E)-2-nitro-vinyl)-phenol
• 英文别名: 2,6-Dimethyl-4-(2-nitroethenyl)phenol；2,6-dimethyl-4-[(E)-2-nitroethenyl]phenol
• CAS: 210057-08-2
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: ULOPZCZOKDOQOX-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Antitumor Agent
  申请人：Arai Hitoshi

  公开号：US20090012060A1

  公开（公告）日：2009-01-08

  The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein —X—Y-Z- represents —O—CR 3 ═N— (wherein R 3 represents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, R 1 represents —NR 10 R 11 (wherein R 10 and R 11 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, R 2 represents —NR 13 R 14 (wherein R 13 and R 14 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

  本发明提供了一种抗肿瘤剂及类似物，其包括一种以嘧啶衍生物为活性成分，其表示为式（I）：[其中- X-Y-Z-表示-O-CR3═N-（其中R3表示氢原子，取代或未取代的芳香族杂环基等），R1表示-NR10R11（其中R10和R11可以相同或不同，且每个表示氢原子，取代或未取代的较低烷基等），R2表示-NR13R14（其中R13和R14可以相同或不同，且每个表示氢原子，取代或未取代的较低烷基等）]或其药学上可接受的盐。
• ANTI-TUMOR AGENT
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1749827A1

  公开（公告）日：2007-02-07

  The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein -X-Y-Z- represents -O-CR3=N- (wherein R3 represents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, R1 represents -NR10R11 (wherein R10 and R11 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, R2 represents -NR13R14 (wherein R13 and R14 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

  本发明提供了一种抗肿瘤剂等，其活性成分包括由式（I）表示的嘧啶衍生物： [其中-X-Y-Z-代表-O-CR3=N-（其中 R3 代表氢原子、取代或未取代的芳香杂环基等）等，R1 代表-NR10R11（其中 R10 和 R11 可以相同或不同，各自代表氢原子、R2代表-NR13R14（其中R13和R14可以相同或不同，且各自代表氢原子、取代或未取代的低级烷基等）]或其药学上可接受的盐。
• NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20140135325A1

  公开（公告）日：2014-05-15

  The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.
• US7956060B2
  申请人：——

  公开号：US7956060B2

  公开（公告）日：2011-06-07
• US9522908B2
  申请人：——

  公开号：US9522908B2

  公开（公告）日：2016-12-20