Dipotassium 1-oxo-3H-isobenzofuran-3,3-diylbis(p-phenylene) bis(sulphate) | 52322-16-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: Dipotassium 1-oxo-3H-isobenzofuran-3,3-diylbis(p-phenylene) bis(sulphate)
• 英文别名: [4-[3-oxo-1-(4-sulfooxyphenyl)-2-benzofuran-1-yl]phenyl] hydrogen sulfate
• CAS: 52322-16-4；10059-42-4
• 化学式: C₂₀H₁₄O₁₀S₂
• 分子量: 478.5
• InChiKey: MVIHXDVCXNPIAL-UHFFFAOYSA-N

物化性质

• 熔点：
  230 °C
• 密度：
  1.679±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  170
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• HIRUDIN ANALOGUE OR SALT THEREOF, PRODUCTION THEREOF, AND ANTICOAGULANT CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：JAPAN ENERGY CORPORATION

  公开号：EP0531537A1

  公开（公告）日：1993-03-17

  A hirudin analogue having high antithrombin activity and platelet aggregation resistance, represented by formula Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) and having a tyrosine residue with its hydroxyl group optionally sulfated. In the said formula, A represents Glu or Pro; B represents Glu, Tyr(R), Glu-Asp or Glu-Tyr(R); and (R) represents the hydroxyl group of a tyrosine residue or the sulfate thereof (-O-SO₃H). A process for producing a hirudin analogue by sulfating the hydroxyl group of the tyrosine residue. An anticoagulant containing the hirudin analogue (I) as the active ingredient.

  一种具有高抗凝血酶活性和抗血小板聚集性的水蛭素类似物，由式 Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) 表示，其酪氨酸残基的羟基可选择硫酸化。在所述式中，A 代表 Glu 或 Pro；B 代表 Glu、Tyr(R)、Glu-Asp 或 Glu-Tyr(R)；(R) 代表酪氨酸残基的羟基或其硫酸盐（-O-SO₃H）。一种通过硫酸化酪氨酸残基的羟基来生产水蛭素类似物的工艺。一种含有水蛭素类似物(I)作为活性成分的抗凝剂。
• Biological indicator
  申请人：American Sterilizer Company

  公开号：US10011843B2

  公开（公告）日：2018-07-03

  This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

  本发明涉及一种生物指示剂，其成分包括：由形成孢子的细菌组成的宿主生物；产生指示剂酶的报告基因；调控基因；以及将报告基因和调控基因插入宿主生物的载体；宿主生物的基因组中含有转座遗传因子，用于在调控基因中插入插入序列；插入序列包括转座酶、一对末端倒置重复序列和至少一个用于表达转座酶的开放阅读框。载体可被宿主生物吸收。插入序列可插入调控基因中。宿主生物可进行孢子繁殖以形成生物指示剂。本发明公开了一种使用生物指示剂的工艺和装置。
• Method for detecting Escherichia coli in a sample
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10023898B2

  公开（公告）日：2018-07-17

  A method of detecting Listeria monocytogenes. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system. The selective culture medium facilitates the growth of Listeria microorganisms. When a Listeria microorganism is detected in a sample contacted with the culture medium, the detection article is contacted with the culture medium to detect Listeria monocytogenes.

  一种检测李斯特菌的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。选择性培养基有利于李斯特菌微生物的生长。当在与培养基接触的样品中检测到李斯特菌微生物时，检测物品与培养基接触以检测单增李斯特菌。
• Method for detecting a Shigella or Cronobacter microorganism
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10619181B2

  公开（公告）日：2020-04-14

  A method of detecting a Shigella or Cronobacter microorganism. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system.

  一种检测志贺氏菌或克罗诺斯菌微生物的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。
• Biological disinfection or sterilization indicator
  申请人：TERRAGENE LLC

  公开号：US11001799B2

  公开（公告）日：2021-05-11

  A biological indicator for testing the efficacy of sterilization or disinfection processes of closed environments or confined spaces, the biological indicator comprising a carrier; biological material supported on or embedded in the carrier; and a carrier container comprising a body and a cap. The carrier is fixed within an inner space of the cap, the cap being able to be placed in an open position completely exposing the carrier and the biological material to the closed environment or confined space to be disinfected. A method for determine the efficacy of a process of sterilization or disinfection of closed environments or confined spaces, preferably by means of an enzyme and a fluorescence compound, using said biological indicator.

  一种生物指示器，用于检测封闭环境或密闭空间的灭菌或消毒过程的功效，该生物指示器包括一个载体；支撑在载体上或嵌入载体的生物材料；以及一个由主体和盖子组成的载体容器。载体固定在盖子的内部空间中，盖子可置于打开位置，使载体和生物材料完全暴露在要消毒的封闭环境或密闭空间中。一种确定封闭环境或密闭空间灭菌或消毒过程有效性的方法，最好是通过酶和荧光化合物，使用所述生物指示剂。