葫芦素L | 1110-02-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 葫芦素L
• 英文名称: cucurbitacin L
• 英文别名: cucurbitacins L；(8S,9R,10R,13R,14S,16R,17R)-17-[(2R)-2,6-dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione
• CAS: 1110-02-7
• 化学式: C₃₀H₄₄O₇
• 分子量: 516.675
• InChiKey: PIGAXYFCLPQWOD-ILFSFOJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  bryoamaride 在 lyophilized gastric juices of grape snail 、 苯 作用下， 以 水 为溶剂， 反应 240.0h， 生成 葫芦素L
  参考文献：
  名称：

  Bryonia isoprenes. II. Cucurbitacin L and bryoamaride fromBryonia melanocarpa

  摘要：

  Cucurbitacin L and bryoamaride, the predominant components of the bitter principle of Bryonia melanocarpa Nab. (Cucurbitaceae), are isolated from the roots of the plant.

  DOI：

  10.1007/bf02238339

文献信息

• COMPOSITION FOR PROMOTING SECRETION OF EXTRACELLULAR VESICLES
  申请人：Nissan Chemical Corporation

  公开号：EP3950060A1

  公开（公告）日：2022-02-09

  This is to provide a composition for promoting secretion of extracellular vesicles. Provided is a composition for promoting secretion of extracellular vesicles, which comprises a compound having a structure of the formula I (wherein each substituent is as defined in the specification), a racemate thereof or a stereoisomer thereof, or a salt thereof, or a compound having a structure of the formula II (wherein each substituent is as defined in the specification), or a stereoisomer thereof, or a salt thereof, or, cucurbitacin, or a stereoisomer thereof, or a salt thereof.

  这是为了提供一种促进细胞外囊泡分泌的组合物。 本发明提供了一种促进细胞外囊泡分泌的组合物，它包括具有式 I 结构的化合物（其中每个取代基均如说明书中所定义）、其外消旋体或其立体异构体或其盐，或具有式 II 结构的化合物（其中每个取代基均如说明书中所定义）、其立体异构体或其盐，或葫芦素、其立体异构体或其盐。
• Chemosensory receptor ligand-based therapies
  申请人：Anji Pharma (US) LLC

  公开号：US10610500B2

  公开（公告）日：2020-04-07

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含化感受体配体（如苦味受体配体）的组合物来治疗与化感受体相关的病症（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了化学感觉受体配体组合物，包括苦味受体配体组合物，及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• METHOD OF MAKING MEDICAMENT FOR TREATING ANEMIA
  申请人：Xing Hongtao

  公开号：US20060246161A1

  公开（公告）日：2006-11-02

  Method and pharmaceutical composition for treating anemia related symptoms. The method and formulation involve the use of one or more cucurbitacin analogs as active ingredients, for example, cucurbitacin D, which are capable of increasing hemoglobin expression, reactivating fetal or adult hemoglobin and inducing γ-globin.

  治疗贫血相关症状的方法和药物组合物。 该方法和制剂涉及使用一种或多种葫芦素类似物作为活性成分，例如葫芦素 D，它们能够增加血红蛋白的表达，重新激活胎儿或成人血红蛋白，并诱导γ-球蛋白。
• The Constituents of Ecballium elaterium L. III. Elatericin A and B^1,2
  作者：David Lavie、David Willner

  DOI：10.1021/ja01536a047

  日期：1958.2
• Constituents of Citrullus colocynthis (L.) Schrad.
  作者：D. Lavie、D. Willner、Z. Merenlender

  DOI：10.1016/s0031-9422(00)83994-1

  日期：1964.1