Choline methyl ether | 25728-47-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Choline methyl ether
• 英文别名: 2-methoxyethyl(trimethyl)azanium;hydrochloride
• CAS: 25728-47-6
• 化学式: C6H17ClNO+
• 分子量: 154.66
• InChiKey: MSIGGUSMCUUDGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Gamma lactams as prostaglandin agonists and use thereof
  申请人：Araldi Luca Gian

  公开号：US20050288357A1

  公开（公告）日：2005-12-29

  1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.

  本发明提供了1,2-取代的5-吡咯烷酮化合物，并提供了利用或包含一个或多个此类化合物的治疗方法和制药组合物。本发明的化合物可用于各种治疗方案，包括治疗或预防早产、痛经、哮喘、高血压、不孕或生育障碍、不良血液凝固、先兆子痫或子痫、嗜酸性粒细胞异常、性功能障碍、骨质疏松和其他骨骼疾病或障碍、肾功能障碍、免疫缺陷性疾病、干眼症、鱼鳞病、眼内压升高、睡眠障碍或胃溃疡、炎症性疾病和其他与前列腺素类化合物有关的疾病和障碍。
• G-lactam derivatives as prostaglandin agonists
  申请人：Araldi Luca Gian

  公开号：US20060194865A1

  公开（公告）日：2006-08-31

  The present invention relates γ-lactam derivatives, in particular for use as medicaments, as well as pharmaceutical formulations containing such γ-lactam derivatives. Said γ-lactam derivatives are useful in the treatment and/or prevention of asthma, hypertension, osteoporosis, sexual dysfunction and fertility disorders.

  本发明涉及γ-内酰胺衍生物，特别是用作药物，以及含有这种γ-内酰胺衍生物的制药配方。所述γ-内酰胺衍生物在哮喘、高血压、骨质疏松症、性功能障碍和生育障碍的治疗和/或预防中有用。
• Pyrrolidin-2-One Derivatives for Use as Dp1 Receptor Agonists
  申请人：Araldi Luca Gian

  公开号：US20080027126A1

  公开（公告）日：2008-01-31

  The present invention is directed to compounds that may be used as agonists of prostaglandin receptors. More specifically, the specification describes methods and compositions for making and using DP1 receptor agonists that are pyrrolidin-2-one derivatives.

  本发明涉及可用作前列腺素受体激动剂的化合物。更具体地，本说明书描述了制备和使用吡咯烷-2-酮衍生物的DP1受体激动剂的方法和组合物。
• Hydrazide derivatives as prostaglandin receptors modulators
  申请人：Araldi Luca Gian

  公开号：US20070185191A1

  公开（公告）日：2007-08-09

  The present invention relates to hydrazide derivatives of Formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.

  本发明涉及公式I的肼酰肼衍生物，特别是用作药物活性化合物，以及包含这种肼酰肼衍生物的制药配方。所述肼酰肼衍生物在早产、痛经、生育障碍、哮喘、高血压、不良血液凝固、先兆子痫、子痫前期、嗜酸性细胞异常增多症、不良骨质流失、肾功能障碍、免疫缺陷病、鱼鳞病、眼内压增高、不孕不育、性功能障碍、胃溃疡和炎症性疾病的治疗中有用。
• Biologically active oils
  申请人：Turner Athol Gillies

  公开号：US20060183799A1

  公开（公告）日：2006-08-17

  A process for the production of fats or oils and their extracts containing biologically-active chemical compounds from a lipid substrate, the process comprising: a) inoculation of a lipid substrate with fungally derived lipolytic enzymes b) incubating the inoculated substrate for a period of between about 7-120 days at a temperature of between about 4-35° C., at a humidity of between about 75-100%, and C) processing said substrate mixture to obtain a biologically active fat or oil.

  一种从脂质基质中生产含有生物活性化合物的脂肪或油及其提取物的工艺，该工艺包括：a) 用真菌衍生的脂肪分解酶接种脂质基质；b) 在温度约为 4-35°C 之间，湿度约为 75-100% 之间，将接种的基质培养约 7-120 天；以及 C) 处理所述基质混合物，以获得具有生物活性的脂肪或油。