Disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-3-pyrrolidin-1-ylpropyl]phosphinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-3-pyrrolidin-1-ylpropyl]phosphinate
• 化学式: C7H15NNa2O7P2
• 分子量: 333.12
• InChiKey: IWLDTXOHXPDPQG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -7.78
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  144
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Pharmacologically active agents containing esterified phosphonates and methods for use thereof
  申请人：Hostetler Y. Karl

  公开号：US20050192246A1

  公开（公告）日：2005-09-01

  Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.

  提供了用于治疗、预防或改善与病毒感染、细胞增殖和骨代谢相关的各种医学疾病的化合物和组合物。本文提供的化合物是磷酸酯的烷基酯。
• Pharmacologically Active Agents Containing Esterified Phosphonates and Methods for Use Thereof
  申请人：Hostetler Karl Y.

  公开号：US20100273742A1

  公开（公告）日：2010-10-28

  Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.

  本发明提供了用于治疗、预防或改善与病毒感染、细胞增殖和骨代谢有关的各种医疗障碍的化合物和组合物。本文提供的化合物是磷酸酯的烷基酯。
• PERCUTANEOUS PREPARATIONS
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1475095A1

  公开（公告）日：2004-11-10

  A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid, etc., or pharmaceutically acceptable salts thereof, a solubilizing agent for the derivative or pharmaceutically acceptable salts thereof, and an amphiphilic solubilizing auxiliary agent, which may optionally contain a suspension-type base such as a polyvalent alcohol, a higher fatty acid ester, a liquid hydrocarbon or a vegetable oil, etc. This preparation has an excellent percutaneous permeability, reduces burdens on the patient, does not deteriorate the patient's compliance even in the administration over a prolonged period of time and can achieve the therapeutic effects in a short period of time.

  一种经皮渗透性极佳的含双膦酸衍生物的经皮制剂，包括一种双膦酸衍生物，如英卡膦酸、米诺膦酸等，或其药学上可接受的盐；一种用于该衍生物或其药学上可接受的盐的增溶剂；以及一种两性增溶辅助剂，该辅助剂可选择性地含有悬浮型基质，如多价醇、高级脂肪酸酯、液态烃或植物油等。这种制剂具有良好的经皮渗透性，可减轻患者的负担，即使长期给药也不会降低患者的依从性，并能在短时间内达到治疗效果。
• N-HETEROCYCLIC PROPYLIDENE-1,1-BISPHOSPHONIC ACIDS, THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION
  申请人：LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)

  公开号：EP0409881B1

  公开（公告）日：1993-02-10
• Percutaneous preparations
  申请人：Tsuji Yasuhiro

  公开号：US20050106186A1

  公开（公告）日：2005-05-19

  A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid, etc., or pharmaceutically acceptable salts thereof, a solubilizing agent for the derivative or pharmaceutically acceptable salts thereof, and an amphiphilic solubilizing auxiliary agent, which may optionally contain a suspension-type base such as a polyvalent alcohol, a higher fatty acid ester, a liquid hydrocarbon or a vegetable oil, etc. This preparation has an excellent percutaneous permeability, reduces burdens on the patient, does not deteriorate the patient's compliance even in the administration over a prolonged period of time and can achieve the therapeutic effects in a short period of time.