[(8S,9R,10S,11S,13S,14S,17R)-9-氟-11-羟基-17-(2-羟基乙酰基)-10,13-二甲基-3-氧代-6,7,8,11,12,14,15,16-八氢环戊烯并[a]菲-17-基]丁酸酯 | 68791-47-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: [(8S,9R,10S,11S,13S,14S,17R)-9-氟-11-羟基-17-(2-羟基乙酰基)-10,13-二甲基-3-氧代-6,7,8,11,12,14,15,16-八氢环戊烯并[a]菲-17-基]丁酸酯
• 英文名称: 9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17-butyrate
• 英文别名: [(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
• CAS: 68791-47-9
• 化学式: C₂₅H₃₃FO₆
• 分子量: 448.5
• InChiKey: JMNCBDUSHPYROE-ZLOBPOPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• MOTOR-ASSOCIATED NEURODEGENERATIVE DISEASE AND METHODS OF TREATMENT
  申请人：Verge Analytics, Inc.

  公开号：US20170360805A1

  公开（公告）日：2017-12-21

  Disclosed herein are methods and compounds for treating a motor-associated neurodegenerative disease or condition. In some instances, also included herein are methods and compounds for treating a TDP-43 associated neurodegenerative disease or condition (e.g., ALS and frontotemporal dementia) and/or a C9orf72 associated neurodegenerative disease or condition (e.g., ALS and frontotemporal dementia).