N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide;hydron;dichloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide;hydron;dichloride
• 化学式: C24H27Cl3FN5O3
• 分子量: 558.9
• InChiKey: JZZFDCXSFTVOJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.24
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  88.6
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Polymorphic forms/hydrates of n-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochloride
  申请人：——

  公开号：US20040034022A1

  公开（公告）日：2004-02-19

  There are described polymorphic forms/hydrates of N-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide dihydrochloride, processes for their preparation, as well as the use of the same for the preparation of medicaments with irreversible tyrosine kinase inhibiting action.

  本文描述了N-[4-(3-氯-4-氟苯基氨基)-7-(3-吗啡啉-4-基丙氧基)-喹唑啉-6-基]丙烯酰胺二盐酸盐的多态形式/水合物，其制备方法，以及将其用于制备具有不可逆酪氨酸激酶抑制作用的药物的用途。
• Use of a composition comprising a retinoid and an erb inhibitor in the preparation of a medicament for the treatment of retinoid skin damage
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1230919A2

  公开（公告）日：2002-08-14

  Erb inhibitors used in combination with retinoids are effective to prevent skin injury otherwise caused by retinoids alone. A method of treating skin aging and similar skin disorders comprises administering retinoids in combination with erb inhibitors of the general formula where E1, E2, and E3 include halo, aryl is an alkylcarbonyl or alkenylcarbonyl, and alkoxy is lower alkoxy optionally substituted with amino groups.

  Erb 抑制剂与维甲酸类药物结合使用，可有效防止维甲酸类药物单独使用造成的皮肤损伤。一种治疗皮肤老化和类似皮肤病的方法包括将维甲酸与通式为 Erb 的抑制剂联合使用 其中 E1、E2 和 E3 包括卤代，芳基是烷基羰基或烯基羰基，烷氧基是任选被氨基取代的低级烷氧基。
• NOVEL COMBINATIONAL USE OF SULFONAMIDE COMPOUND
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1859793A1

  公开（公告）日：2007-11-28

  The present invention relates to a pharmaceutical composition, a kit and a method for treating cancer, comprising a sulfonamide compound in combination with a substance having an EGF inhibitory activity.

  本发明涉及一种治疗癌症的药物组合物、试剂盒和方法，其中包括磺酰胺化合物与具有表皮生长因子抑制活性的物质的组合。
• Material and methods for treating or preventing HER-3 associated diseases
  申请人：U3 Pharma GmbH

  公开号：EP2719708A2

  公开（公告）日：2014-04-16

  Described herein are materials and methods for treating subjects having a HER-3 associated disease, by administering a first agent that binds to HER-3, in combination with a second agent that binds and/or inhibits another member of the HER family. The first and the second agent may be a biologic, such as an antigen-binding protein, or a small molecular tyrosine kinase inhibitor, for example.

  本文描述了通过施用与HER-3结合的第一种制剂和与HER家族另一成员结合和/或抑制该成员的第二种制剂，治疗患有HER-3相关疾病的受试者的材料和方法。第一种药剂和第二种药剂可以是生物制剂，例如抗原结合蛋白或小分子酪氨酸激酶抑制剂。
• Method for inhibiting retinoid skin damage
  申请人：——

  公开号：US20020169176A1

  公开（公告）日：2002-11-14

  Erb inhibitors used in combination with retinoids are effective to prevent skin injury otherwise caused by retinoids alone. A method of treating skin aging and similar skin disorders comprises administering retinoids in combination with erb inhibitors of the general formula 1 where E 1 , E 2 , and E 3 include halo, aryl is an alkylcarbonyl or alkenylcarbonyl, and alkoxy is lower alkoxy optionally substituted with amino groups.

  Erb 抑制剂与维甲酸类药物结合使用，可有效防止维甲酸类药物单独使用造成的皮肤损伤。一种治疗皮肤老化和类似皮肤疾病的方法包括将维甲酸与通式为 1 式中 E 1 , E 2 和 E 3 包括卤素，芳基是烷基羰基或烯基羰基，烷氧基是可选被氨基取代的低级烷氧基。