毒理性
哺乳期间使用总结：本记录中的信息指的是锝Tc 99m美罗酸盐（锝Tc 99m亚甲基二膦酸盐；锝Tc 99m MDP）作为诊断剂的使用。美国核能管理委员会的一个小组委员会建议，在给予所有锝Tc 99m诊断产品后，为了简化指导建议，应停止哺乳24小时，尽管这个时间间隔可能比必要的要长。国际辐射防护委员会也建议，在给予锝Tc 99m美罗酸盐后，不需要中断哺乳。然而，为了遵循将暴露量“尽可能合理地降至最低”的原则，一些专家建议在给予放射性药物前哺乳婴儿，并在剂量后中断哺乳3到6小时，然后完全挤出一次乳汁并丢弃。如果母亲在检查前已经挤出并保存了乳汁，她可以在哺乳中断期间用它喂养婴儿。母亲在通常的临床剂量后不需要避免与婴儿亲密接触。
担心乳汁中放射活度水平的母亲可以要求在医院核医学科进行测试。当放射活性处于安全水平时，她可以恢复哺乳。已经发表了一种测量乳汁放射活性并确定母亲可以安全恢复哺乳的时间的方法。
对于在工作场所接触Tc 99m物质的哺乳母亲，除了适当的普通辐射防护措施外，不需要采取任何预防措施。
◉ 对哺乳婴儿的影响：截至修订日期，未找到相关已发表信息。
◉ 对哺乳和乳汁的影响：截至修订日期，未找到相关已发表信息。
◉ Summary of Use during Lactation:Information in this record refers to the use of technetium Tc 99m medronate (Tc 99m methylene diphosphonate; Tc 99m MDP) as a diagnostic agent. A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary. The International Commission on Radiological Protection also recommends that breastfeeding need not be interrupted after administration technetium Tc 99m medronate. However, to follow the principle of keeping exposure "as low as reasonably achievable", some experts recommend nursing the infant just before administration of the radiopharmaceutical and interrupting breastfeeding for 3 to 6 hours after the dose, then expressing the milk completely once and discarding it. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption. Mothers need not refrain from close contact with their infants after usual clinical doses.
Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.
For nursing mothers who work with Tc 99m substances in their workplace, there is no need to take any precautions other than those appropriate for general radiation protection.
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
