Epichlorohydrin triethanolamine | 68141-08-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Epichlorohydrin triethanolamine
• 英文别名: 2-[bis(2-hydroxyethyl)amino]ethanol;2-(chloromethyl)oxirane
• CAS: 68141-08-2
• 化学式: C9H20ClNO4
• 分子量: 241.71
• InChiKey: XSNSOQNHJHPRQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.11
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.5
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Immunoassay method using a multizone test device
  申请人：MILES INC.

  公开号：EP0249851A2

  公开（公告）日：1987-12-23

  A multizone test device for the determination of analyte in a liquid test medium. The test device preferably comprises multilayers including a first layer comprising a solid, porous matrix incorporated with a reversibly immobilized first reagent and a second layer comprising a solid, porous matrix incorporated with a second reagent which interacts with the first reagent and analyte from the liquid test medium to provide a detectable signal. A reversible binding interaction between the first reagent and the matrix of the first layer prevents the first reagent from prematurely migrating into the second layer during manufacture of the device and prior to application of the liquid test medium to the test device. The reversible binding interaction is sufficiently disruptable by contact of the first layer with the liquid test medium to release and thereby render diffusible an analytically effective amount of the first reagent within the test device.

  一种多区测试装置，用于测定液体测试介质中的分析物。该测试装置最好包括多层膜，其中第一层由固体多孔基质组成，内含可逆固定的第一试剂；第二层由固体多孔基质组成，内含第二试剂，第二试剂与第一试剂和液体测试介质中的分析物相互作用，提供可检测的信号。第一试剂与第一层基质之间的可逆结合作用可防止第一试剂在设备制造过程中和将液体测试介质应用到测试设备之前过早迁移到第二层。第一层与液体测试介质接触后，这种可逆的结合作用就会被充分破坏，从而释放出测试装置内分析有效量的第一试剂，并使其扩散。
• Protein assay device and method
  申请人：CAMBRIDGE LIFE SCIENCES PLC

  公开号：EP0310314A1

  公开（公告）日：1989-04-05

  An IgG dipstick or other device is disclosed for the colourimetric detection of IgG in a sample in the presence of other proteins. The dipstick or other device comprises a porous ion exchange member 1, e.g. of ion exchange filter paper, into which the IgG containing sample is drawn by capillary attraction. The pH of the sample is adjusted to the isoelectric point of IgG, and due to the faster diffusion rate of IgG at its isoelectric point as compared with other proteins in the sample which have different isoelectric points, IgG is preferentially separated from the other proteins and its presence is detected by a band of protein reactive dye 2 incorporated into the porous ion exchange member at a predetermined distance from the point of application of the protein sample.

  本发明公开了一种 IgG 滴管或其他装置，用于在有其他蛋白质存在的情况下对样品中的 IgG 进行比色检测。IgG检测棒或其他装置由多孔离子交换部件1（如离子交换滤纸）组成，含有IgG的样品通过毛细管吸力被吸入其中。样品的 pH 值调节到 IgG 的等电点，由于 IgG 在等电点的扩散速度快于样品中具有不同等电点的其他蛋白质，IgG 会优先从其他蛋白质中分离出来，并通过多孔离子交换构件中的蛋白质活性染料 2 带在距离蛋白质样品应用点的预定距离上检测其存在。
• Preparation and use of particulates composed of adenovirus particles
  申请人：——

  公开号：US20020006412A1

  公开（公告）日：2002-01-17

  This invention provides particulates of adenoviral particles comprised of individual adenovirus virions complexed to an insoluble micro-platform material and for such compositions further comprised of a polynucleotide encoding an antigenic peptide. The invention further provides method for forming such complexes such that the compositions are useful for transfecting phagocytic antigen presenting cells such as dendritic cells and for vaccinating a subject against disease.

  本发明提供了由与不溶性微平台材料复合的单个腺病毒病毒组成的腺病毒颗粒微粒，以及进一步由编码抗原肽的多核苷酸组成的此类组合物。本发明进一步提供了形成这种复合物的方法，从而使这种复合物可用于转染吞噬性抗原呈递细胞（如树突状细胞）和为受试者接种抗病疫苗。
• Method and apparatus for increasing flux during reverse iontophoresis
  申请人：——

  公开号：US20030065285A1

  公开（公告）日：2003-04-03

  The present invention provides a method and device that substantially increases reverse iontophoretic flux and therefore, noninvasive extraction of uncharged and charged permeant molecules alike through the skin. By substituting the mobile co-ions, which are capable of easily entering the pores from the receiver compartment of a reverse iontophoretic extraction device with large conductive polyelectrolytes within the reservoir that do not appreciably enter the pores, the invention significantly improves the amount of analyte extracted, improves device performance, decreases energy requirements, increases battery life, reduces the potential for irritation, and improves accuracy, reproducibility, and precision.

  本发明提供了一种方法和装置，可大幅提高反向离子渗透通量，从而实现通过皮肤无创提取不带电和带电的渗透分子。本发明用储液器中不会明显进入毛孔的大分子导电聚电解质取代了容易从反向离子渗透萃取装置的接收器舱进入毛孔的移动共离子，从而显著提高了分析物的萃取量，改善了装置性能，降低了能量要求，延长了电池寿命，减少了潜在的刺激性，并提高了准确性、再现性和精确度。
• Method for stabilizing flux and decreasing lag-time during iontophoresis
  申请人：——

  公开号：US20030065305A1

  公开（公告）日：2003-04-03

  An iontophoretic method for transporting compounds of interest across a body tissue is provided. The method can be used to extract analytes or deliver drugs. The method utilizes a polyelectrolyte and provides for the maintenance of a substantially constant flux across a localized region of the tissue through which transport occurs, thereby allowing a compound of interest to be transported across the tissue in a controlled and predictable manner. In addition, the presence of the polyclectrolyte reduces the lag-time of molecular transport through the body tissue.

  本文提供了一种在人体组织中传输相关化合物的离子渗透方法。该方法可用于提取分析物或输送药物。该方法利用一种聚电解质，在组织的局部区域保持基本恒定的通量，从而以可控和可预测的方式在组织间传输感兴趣的化合物。此外，聚电解质的存在还能减少分子在身体组织中迁移的滞后时间。