Cytidine5-monophosphate | 170151-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: Cytidine5-monophosphate
• 英文别名: 4-(aminomethyl)-3-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2-thione
• CAS: 170151-25-4
• 化学式: C₁₄H₁₅F₂N₃S
• 分子量: 295.35
• InChiKey: YZZVIKDAOTXDEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods for Treating Dependence
  申请人：Woiwode Tom

  公开号：US20090041800A1

  公开（公告）日：2009-02-12

  Provided are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance with Compound A. Also provided are methods of treating at least one phase of substance dependence on at least one substance in patients and certain methods of treating at least one phase of cocaine dependence in patients.

  提供了使用化合物A治疗患有或易受至少一种物质滥用、依赖或戒断症状的患者的方法。还提供了治疗患者至少一种物质依赖的方法以及治疗患者可卡因依赖至少一种阶段的方法。
• Treatment of Post-Traumatic Stress Disorder
  申请人：Woiwode Tom

  公开号：US20090054403A1

  公开（公告）日：2009-02-26

  Provided are methods of treating a patient diagnosed with post-traumatic stress disorder, by administering to the patient a therapeutically effective amount of Compound A. Also provided are methods of improving resilience in a patient by administering a therapeutically effective amount of Compound A. Also provided are methods of diagnosing post-traumatic stress disorder in a patient by administering to the patient a therapeutically effective amount of Compound A and assessing at least one of sign, symptom, or symptom cluster of post-traumatic stress disorder; and diagnosing post-traumatic stress disorder in the patient if the Compound A reduces at least one of sign, symptom, and symptom cluster of post-traumatic stress disorder.

  提供了一种治疗创伤后应激障碍患者的方法，即向患者施用治疗有效量的A化合物。此外，还提供了一种通过向患者施用治疗有效量的A化合物来提高患者适应力的方法。还提供了一种通过向患者施用治疗有效量的A化合物并评估创伤后应激障碍的至少一个体征、症状或症状群，来诊断患者是否患有创伤后应激障碍的方法；如果A化合物减轻了创伤后应激障碍的至少一个体征、症状或症状群，则诊断患者患有创伤后应激障碍。
• Methods for treating dependence
  申请人：Biotie Therapies, Inc.

  公开号：US10561638B2

  公开（公告）日：2020-02-18

  Provided are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance with Compound A. Also provided are methods of treating at least one phase of substance dependence on at least one substance in patients and certain methods of treating at least one phase of cocaine dependence in patients.

  还提供了治疗患者对至少一种物质的至少一个阶段的物质依赖的方法，以及治疗患者对可卡因的至少一个阶段的依赖的某些方法。
• METHODS FOR TREATING DEPENDENCE
  申请人：Biotie Therapies, Inc.

  公开号：EP2182804B1

  公开（公告）日：2017-05-24
• BENZOCYCLOALKYLAZOLETHIONE DERIVATIVES
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0757677A1

  公开（公告）日：1997-02-12