1,7-Heptanediamine, N-(3-aminopropyl)- | 25712-59-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,7-Heptanediamine, N-(3-aminopropyl)-
• 英文别名: N'-(3-aminopropyl)heptane-1,7-diamine
• CAS: 25712-59-8
• 化学式: C₁₀H₂₅N₃
• 分子量: 187.33
• InChiKey: KQOXSPQVMQIHRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• An amide derivative of amythiamicin
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0825194A2

  公开（公告）日：1998-02-25

  A novel amide derivative of amythiamicin is now provided, which is represented by the general formula (I) wherein n is an integer of 1 to 6, R1 is a hydrogen atom, a carboxyl group or a hydroxylmethyl group, and R2 is a group of the formula -COOR3 where R3 is a hydrogen atom or a lower alkyl group or a benzyl group optionally substituted by a halogen or a hydroxyl group, or R2 is a group of the formula -NR4R5 where R4 is a hydrogen atom or a lower alkyl group and R5 is a hydrogen atom, a lower alkyl group, 3-aminopropyl group, 3-[2-(p-chloro or bromophenyl)ethyl]aminopropyl group or 3-(n-butylamino)propyl group, or R2 is a methyl group, a hydroxyl group or a guanidino group of the formula -NH-C(=NH)-NH2, or a pharmaceutically acceptable salt or ester thereof. These compounds of the formula (I) exhibit useful antibacterial activities and are soluble in water, and some of them are found to exhibit an excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

  现提供一种新型的氨基硫胺酰胺衍生物，其通式为(I) 其中 n 为 1 至 6 的整数，R1 为氢原子、羧基或羟甲基，R2 为式 -COOR3 的基团，其中 R3 为氢原子或低级烷基或任选被卤素或羟基取代的苄基，或 R2 为式 -NR4R5 的基团，其中 R4 为氢原子或低级烷基，R5 为氢原子、低级烷基、3-氨基丙基、3-[2-（对氯或溴苯基）乙基]氨基丙基或 3-（正丁氨基）丙基，或 R2 为甲基、羟基或式 -NH-C(=NH)-NH2 的胍基，或其药学上可接受的盐或酯。这些式（I）化合物表现出有用的抗菌活性，并可溶于水，其中一些对耐甲氧西林金黄色葡萄球菌（MRSA）表现出优异的抗菌活性。
• COMPOSITIONS AND METHODS FOR PRODUCING POLY-AMINOFUNCTIONALIZED POLYMERIZATION INITIATORS AND CORRESPONDING POLYMERS
  申请人：Bridgestone Corporation

  公开号：EP2475534A1

  公开（公告）日：2012-07-18
• COMPOSITIONS AND METHOD FOR PRODUCING POLY-AMINOFUNCTIONALIZED POLYMERIZATION INITIATORS AND CORRESPONDING POLYMERS
  申请人：Suzuki Eiju

  公开号：US20120259056A1

  公开（公告）日：2012-10-11

  Compositions and methods for producing polymerization initiators comprising at least two protected primary amine groups. Polymers prepared using such polymerization initiators can comprise a residue of the polymerization initiator and can initially comprise the at least two protected primary amine groups. Such polymers can undergo a deprotection process thereby yielding a polymer having one or more unprotected primary amine groups. Polymers having primary amine groups can be employed in rubber compositions, which have a variety of potential applications, such as, for example, in tire manufacturing.
• US6043217A
  申请人：——

  公开号：US6043217A

  公开（公告）日：2000-03-28
• US8729204B2
  申请人：——

  公开号：US8729204B2

  公开（公告）日：2014-05-20