HIGH-PURITY TOCOPHEROL PHOSPHATES, PROCESS FOR THE PREPARATION THEREOF, METHOD FOR ANALYSIS THEREOF, AND COSMETICS
申请人:SHOWA DENKO KABUSHIKI KAISHA
公开号:EP0798305A1
公开(公告)日:1997-10-01
Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'- bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.
本发明公开了一种高纯度生育酚磷酸盐和/或其盐(生育酚磷酸盐),其中 P,P'-双生育酚次磷酸盐和/或其盐(P,P'-双生育酚二磷酸盐)的含量比例不高于 3%(按重量计);一种生产高纯度生育酚磷酸盐和/或其盐的工艺,包括以下步骤:使生育酚与三卤化氧磷反应,然后用酸或碱性水溶液处理,从而形成生育酚磷酸盐(i),其中P、在酸性条件下水解 P,P'-双生育酚二磷酸盐 (ii),并选择性地在碱性条件下使水解产物呈中性或碱性;以及一种分析生育酚磷酸盐的方法,包括使用高效液相色谱仪色谱柱分析含有组分(i)和(ii)的样品,色谱柱中装有聚甲基丙烯酸酯凝胶,该凝胶具有长链烷基。高纯度生育酚磷酸盐中不含有或仅含有极微量的 P,P'-双生育酚二盐,因此高纯度生育酚磷酸盐具有抗氧化和促进血液循环的作用,具有极佳的水溶性,呈粉末状,极易处理,对皮肤无刺激性,无过敏性,确保皮肤安全。因此,高度纯化的生育酚磷酸盐可用作化妆品成分。成分(i)和(ii)的含量可以通过上述方法简单而准确地测量出来。