[1,2-14C]-乙醇胺盐酸盐 | 80335-50-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: [1,2-14C]-乙醇胺盐酸盐
• 英文名称: [1,2-14C]ethanolamine hydrochloride
• 英文别名: Ethanolamine-1,2-14C hydrochloride；2-amino(1,2-14C2)ethanol;hydrochloride
• CAS: 80335-50-8
• 化学式: C₂H₇NO*ClH
• 分子量: 101.523
• InChiKey: PMUNIMVZCACZBB-HMOJLQGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.32
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi,R
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  paclitaxel-10-deacetyl-10-carbonyl-N-methylimidazolinium iodide 、 [1,2-14C]-乙醇胺盐酸盐 在 N,N-二异丙基乙胺 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  In situ blood–brain barrier permeability of a C-10 paclitaxel carbamate

  摘要：

  We report the synthesis and blood-brain barrier (BBB)-permeability of (14)C-CNDR-29, a paclitaxel C-10 carbamate derivative shown to be devoid of P-glycoprotein (Pgp)-interactions, in an in situ mouse brain perfusion model, in comparison with (14)C-paclitaxel. The results presented reveal a 3- to 4-fold higher BBB-permeability for the C-10 modified taxane compared to paclitaxel. These results support the notion that circumvention of Pgp-mediated efflux can lead to higher BBB-permeability. Further studies however are needed to evaluate the therapeutic potential of the C-10 carbamates paclitaxel derivatives for the treatment of CNS diseases. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.024

文献信息

• Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase
  作者：Carmela Saturnino、Stefania Petrosino、Alessia Ligresti、Chiara Palladino、Giovanni De Martino、Tiziana Bisogno、Vincenzo Di Marzo

  DOI：10.1016/j.bmcl.2009.11.134

  日期：2010.2

  N-Acylethanolamines, including N-palmitoyl-ethanolamine (PEA), are hydrolyzed to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH). Recently, N-acylethanolamine-hydrolyzing acid amidase (NAAA) was identified as being able to specifically hydrolyze PEA. In order to find selective and effective inhibitors of this enzyme, we synthesized and screened several amides, retroamides, esters, retroesters and carbamates of palmitic acid (1-21) and esters with C15 and C17 alkyl chains (22-27). Cyclopentylhexadecanoate (13) exhibited the highest inhibitory activity on NAAA (IC50 = 10.0 mu M), without inhibiting FAAH up to 50 mu M. Compound 13 may become a useful template to design new NAAA inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.
• ABIDI, S. L.;IDELSON, A. L., J. LABELLED COMPOUNDS AND RADIOPHARM., 1981, 18, N 8, 1215-1225
  作者：ABIDI, S. L.、IDELSON, A. L.

  DOI：——

  日期：——
• In situ blood–brain barrier permeability of a C-10 paclitaxel carbamate
  作者：Carlo Ballatore、Bin Zhang、John Q. Trojanowski、Virginia M.-Y. Lee、Amos B. Smith

  DOI：10.1016/j.bmcl.2008.10.024

  日期：2008.12

  We report the synthesis and blood-brain barrier (BBB)-permeability of (14)C-CNDR-29, a paclitaxel C-10 carbamate derivative shown to be devoid of P-glycoprotein (Pgp)-interactions, in an in situ mouse brain perfusion model, in comparison with (14)C-paclitaxel. The results presented reveal a 3- to 4-fold higher BBB-permeability for the C-10 modified taxane compared to paclitaxel. These results support the notion that circumvention of Pgp-mediated efflux can lead to higher BBB-permeability. Further studies however are needed to evaluate the therapeutic potential of the C-10 carbamates paclitaxel derivatives for the treatment of CNS diseases. (C) 2008 Elsevier Ltd. All rights reserved.