2,6-dimethylheptane nitrile | 58475-05-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,6-dimethylheptane nitrile
• 英文别名: 2,6-dimethylheptanenitrile；2,6-dimethyl-heptanenitrile；2,6-Dimethyl-heptannitril
• CAS: 58475-05-1
• 化学式: C₉H₁₇N
• 分子量: 139.241
• InChiKey: AHGKTDMTUMZVTH-UHFFFAOYSA-N

物化性质

• 沸点：
  203.3±8.0 °C(Predicted)
• 密度：
  0.813±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-dimethylheptane nitrile 在 溴 、 三溴化磷 作用下， 以 neat (no solvent) 为溶剂， 以90%的产率得到2-bromo-2,6-dimethylheptanenitrile
  参考文献：
  名称：

  铜催化硝基烷烃与α-溴腈的烷基化：β-氰基硝基硝基烷烃的合成

  摘要：

  铜催化现在可以使硝基链烷烃与α-溴腈高效C-烷基化。使用简单且廉价的催化剂，该方法提供了获得β-氰基硝基链烷的途径。该方法高度耐受各种官能团和取代模式。这些功能密集的产物用作正交掩蔽的1,3-二胺，可以选择性地显示出它们以获取差异取代的二胺。这些产物也可用于形成复杂的氰基烯烃和5-氨基异恶唑。

  DOI：

  10.1021/acs.orglett.6b00093
• 作为产物：
  描述：

  6-甲基-2-庚醇 在 吡啶 、 硫酸 作用下， 反应 21.5h， 生成 2,6-dimethylheptane nitrile
  参考文献：
  名称：

  Synthesis and characterization of cis-4-decenoyl-CoA, 3-phenylpropionyl-CoA, and 2,6-dimethylheptanoyl-CoA

  摘要：

  The measurement of acyl-CoA dehydrogenase activities is an essential part of the investigation of patients with suspected defects in fatty acid oxidation. Multiple methods are available for the synthesis of the substrates used for measuring acyl-CoA dehydrogenase activities: however, the yields are low and the products are used without purification. In addition, the reported characterization of acyl-CoAs focuses on the CoA moiety, not on the acyl group. Here we describe the synthesis of three medium-chain acyl-CoAs from mixed anhydrides of the fatty acids using an aqueous-organic solvent mixture optimized to obtain the highest yield. First, cis-4-decenoic acid and 2,6-dimethylheptanoic acid were prepared (3-phenylpropionic acid is commercially available). These were characterized by gas chromatography/mass spectrometry (GC/MS), H-1 nuclear magnetic resonance (NMR), and C-13 NMR. Then cis-4-decenoyl-CoA, 3-phenylpropionyl-CoA, and 2,6-dimethylheptanoyl-CoA were synthesized. These were then purified by ion exchange solid-phase extraction using 2-(2-pyridyl)ethyl-functionalized silica gel, followed by reversed-phase semipreparative high-performance liquid chromatography with ultraviolet detection (HPLC-UV). The purified acyl-CoAs were characterized by analytical HPLC-UV followed by data-dependent tandem mass spectrometry (MS/MS) analysis on the largest responding MS mass (HPLC-UV-MS-MS/MS) and 13C NMR. The yields of the purified acyl-CoAs were between 75% and 78% based on coenzyme A trilithium salt (CoASH). Acyl-CoA dehydrogenase activities were measured in rat skeletal muscle mitochondria using, as substrates, the synthesized cis-4-decenoyl-CoA, 3-phenylpropionyl-CoA, and 2,6-dimethylheptanoyl-CoA. These results were compared with the results using our standard substrates butyryl-CoA, octanoyl-CoA, and palmitoyl-CoA. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.ab.2010.02.026

文献信息

• Electrophotographic photosensitive member, and electrophotgraphic apparatus and process cartridge which make use of the same
  申请人：Canon Kabushiki Kaisha

  公开号：EP1947515A2

  公开（公告）日：2008-07-23

  This invention relates to an electrophotographic photosensitive member having a support and a photosensitive layer. In the electrophotographic photosensitive member having a support and a photosensitive layer, which electrophotographic photosensitive member makes use of, as writing light, a semiconductor laser light ray having a wavelength of from 380 to 500 nm, the photosensitive layer contains a bisazo pigment represented by the following Formula (1): wherein A1, A2 and A3 may be the same or different, and each independently represent a saturated or unsaturated aliphatic hydrocarbon group which may have a substituent, an aromatic hydrocarbon ring group which may have a substituent, a heterocyclic ring group which may have a substituent, or a carbonyl group; R1 and R2 may be the same or different, and each independently represent an alkyl.group which may have a substituent, an aryl group which may have a substituent, or a halogen atom; R3, R4, R5 and R6 may be the same or different, and each independently represent a hydrogen atom, an alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic ring group which may have a substituent, or an aralkyl group which may have a substituent, provided that R3 and R4, and R5 and R6, may each form a cyclic amino group via the nitrogen atom in the formula; Z1 and Z2 each independently represent an oxygen atom or a sulfur atom; m1 and m2 each represent an integer of 0 to 4; and n1, n2 and n3 each independently represent. 0 or 1.

  本发明涉及一种具有支架和感光层的电子照相感光元件。 在这种具有支架和感光层的电子照相感光构件中，该电子照相感光构件利用波长为 380 至 500 纳米的半导体激光光线作为书写光，感光层含有由下式（1）表示的双氮颜料： 其中 A1、A2 和 A3 可以相同或不同，各自独立地代表饱和或不饱和脂肪烃基团（可以有取代基）、芳香烃环基团（可以有取代基）、杂环环基团（可以有取代基）或羰基；R1 和 R2 可以相同或不同，各自独立地代表烷基。R3、R4、R5 和 R6 可以相同或不同，且各自独立地代表氢原子、可 以具有取代基的烷基、可以具有取代基的芳基、可以具有取代基的杂环基团或可以 具有取代基的芳烷基，条件是 R3 和 R4 以及 R5 和 R6 可以各自通过式中的氮原子形 成环状氨基；Z1和Z2各自独立地代表氧原子或硫原子； m1和m2各自独立地代表0至4的整数； n1、n2和n3各自独立地代表。0 或 1。
• A new preparation of β and γ-alkyl aldehydes or acids by using activating cyano group; the synthesis of norphytene
  作者：Marc Larchevěque、Thérèse Cuvigny

  DOI：10.1016/s0040-4039(00)91294-2

  日期：1975.1
• Mukherji, Science and Culture, 1941, vol. 7, p. 58
  作者：Mukherji

  DOI：——

  日期：——
• Mukherjee, Journal of the Indian Chemical Society, 1947, vol. 24, p. 425,431
  作者：Mukherjee

  DOI：——

  日期：——
• [EN] METHODS OF DIAGNOSING AND TREATING NEURODEGENERATIVE DISEASES<br/>[FR] MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：CATHOLIC HEALTHCARE WEST

  公开号：WO2010088400A1

  公开（公告）日：2010-08-05

  The present invention relates to methods of diagnosing, treating and prognosing mental disorders, such as Alzheimer's Disease. In one embodiment, the present invention provides a method of treating Alzheimer's Disease by inhibiting dysfunctional signaling of α7 nAChRs in the medial septum region of an individual.