4-Amino-4-methylpentanenitrile | 1265634-34-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-Amino-4-methylpentanenitrile
• CAS: 1265634-34-1
• 化学式: C₆H₁₂N₂
• mdl: MFCD19215915
• 分子量: 112.175
• InChiKey: DTXRIRLJYYKKJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Amino-4-methylpentanenitrile 、 1-(2,4-二氯苯基)-5-对氯苯基-4-甲基-吡唑-3-甲酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides

  摘要：

  The synthesis and biological evaluation of novel pyrazole-3-carboxamide derivatives as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced. In general, a range of modifications were well tolerated. Several molecules with high polar surface area were also indentified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is exemplified with a lead compound from this series. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.055

文献信息

• [DE] DIETHYLMETHYL-AMMONIUMNITRILE UND WASCH- UND REINIGUNGSMITTEL, ENTHALTEND DIESE AMMONIUMNITRILE<br/>[EN] DIETHYL METHYL AMMONIUM NITRILES AND DETERGENTS AND CLEANING AGENTS CONTAINING SAID AMMONIUM NITRILES<br/>[FR] DIETHYLMETHYL-AMMONIUMNITRILES ET AGENTS DE LAVAGE ET DE NETTOYAGE CONTENANT CES AMMONIUMNITRILES
  申请人：CLARIANT GMBH

  公开号：WO2006024434A1

  公开（公告）日：2006-03-09

  Es werden Diethylmethyl-Ammoniumnitrile der Formel (1) worin A ein Anion bedeutet, beansprucht. Diese Verbindungen eignen sich als Bleichaktivator in Wasch- und Reinigungsmitteln.

  该专利申请涉及化学式为(1)的二乙基甲基铵硝化物，其中A表示阴离子。这些化合物适用于洗涤和清洁剂中的漂白活性剂。
• DIETHYLMETHYL-AMMONIUMNITRILE UND WASCH- UND REINIGUNGSMITTEL, ENTHALTEND DIESE AMMONIUMNITRILE
  申请人：Clariant Produkte (Deutschland) GmbH

  公开号：EP1784385A1

  公开（公告）日：2007-05-16
• SOLIDIFYING COMPOSITION FOR PAPER AND CARDBOARD
  申请人：BASF SE

  公开号：US20170233950A1

  公开（公告）日：2017-08-17

  The invention relates to an aqueous composition comprising (a) polymers having primary amino groups and/or amidine groups to a combined content for these groups of ≧1.5 meq/g of polymer, and (b) 0.01 to 50 mol % of 1,4-cyclohexanedione (b) based on the combined amount of primary amino groups and amidine groups of the polymers, wherein the pH of the aqueous composition is ≦6, and further to its use as strength enhancer and to a method of producing paper and board, employment of the aqueous composition and also the paper and board thus obtained.