Cyclohexa-2,4-dienecarbonitrile | 76356-97-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Cyclohexa-2,4-dienecarbonitrile
• 英文别名: Cyclohexa-2,4-diene-1-carbonitrile
• CAS: 76356-97-3
• 化学式: C₇H₇N
• 分子量: 105.139
• InChiKey: NJAXHGAHWKKQRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• AROMATIC AMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICAL USES OF BOTH
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1813603A1

  公开（公告）日：2007-08-01

  A present invention provides aromatic amide derivatives which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like, and are represented by the general formula (I): wherein R1 represents a hydrogen atom or a C1-6 alkyl group which may have a substituent, R2 is a hydrogen atom or a C1-6 alkyl group, R3 is a hydrogen atom, a C1-6 alkyl group or the like, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, R7 is a hydrogen atom, a heteroaryl group which may have a substituent, a C3-8 cycloalkyl group', an amino group which may have a substituent or a C1-6 alkoxy group which may have a substituted group; M1 is a single bond, a C1-4 alkylene group or the like Y is N or CRF (in the formula, RF represents a hydrogen atom, a C1-6 alkyl group or the like or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or pharmaceutical compositions comprising the same and pharmaceutical uses thereof.

  本发明提供了具有V2受体激动作用的芳香酰胺衍生物，可用作治疗或预防尿崩症、夜尿症、夜间遗尿、膀胱过度活跃或类似疾病的药物，并由通式（I）表示： 其中R1代表氢原子或可能具有取代基的C1-6烷基基团，R2是氢原子或C1-6烷基基团，R3是氢原子、C1-6烷基基团或类似物，R4、R5和R6独立地是氢原子、卤原子或类似物，R7是氢原子、可能具有取代基的杂环基团、C3-8环烷基团、可能具有取代基的氨基团或可能具有取代基的C1-6烷氧基团；M1是单键、C1-4烷基烃基团或类似物，Y是N或CRF（在该式中，RF代表氢原子、C1-6烷基基团或类似物），或其药学上可接受的盐，或其前药，或包含其的药物组合物和药物用途。
• Compositions and methods for expressing genes in algae
  申请人：Synthetic Genomics, Inc.

  公开号：US10041079B2

  公开（公告）日：2018-08-07

  The present application provides novel regulatory elements including promoter sequences from microorganisms. The application further discloses DNA constructs containing these novel regulatory elements, and recombinant microorganisms comprising these regulatory elements. Methods of modifying, producing, and using the regulatory elements are also disclosed. The regulatory elements and transformation methods disclosed herein are particularly suited for use in Parachlorella and other microalgae.

  本申请提供了包括微生物启动子序列在内的新型调控元件。本申请进一步公开了含有这些新型调控元件的 DNA 构建体，以及含有这些调控元件的重组微生物。还公开了改造、生产和使用这些调控元件的方法。本文公开的调控元件和转化方法尤其适用于伞藻和其他微藻类。
• Compositions of and methods for in vitro viral genome engineering
  申请人：C3J THERAPEUTICS, INC.

  公开号：US10221398B2

  公开（公告）日：2019-03-05

  The present disclosure relates to a method of in vitro engineering of nucleic acids. This disclosure further relates to in vitro engineering of viral genomes and to the improvement of viral properties by in vitro genomic engineering of viral genomes. Specifically, the disclosure relates to in vitro viral genomic digestion using RNA-guided Cas9, the assembly of a recombinant genome by the insertion of a DNA or RNA fragment into the digested viral genome and transformation of a host cell with the recombinant genome. This method also related to in vitro engineering for error correction of nucleic acids.

  本公开涉及一种核酸体外工程方法。本公开进一步涉及病毒基因组的体外工程和通过病毒基因组的体外基因组工程改善病毒特性。具体而言，本公开涉及使用 RNA 引导的 Cas9 进行体外病毒基因组消化，通过将 DNA 或 RNA 片段插入消化后的病毒基因组组装重组基因组，以及用重组基因组转化宿主细胞。这种方法还与核酸纠错体外工程有关。
• Regulatory elements from labyrinthulomycetes microorganisms
  申请人：Conagen, Inc.

  公开号：US10633665B2

  公开（公告）日：2020-04-28

  The present disclosure generally relates to novel polynucleotide molecules for use in regulating gene expression in recombinant cells, such as labyrinthulomycetes cells. The disclosure further relates to nucleic acid constructs, such as vectors and expression cassettes, containing a regulatory element operably linked to a heterologous nucleotide sequence. The disclosure further relates to methods for stably transforming a host cell, such as a labyrinthulomycetes cell with transgenes. Stably transformed recombinant cells, progeny, biomaterials derived therefrom, and methods for preparing and using the same are also provided.

  本公开一般涉及用于调节重组细胞（如迷宫菌细胞）中基因表达的新型多核苷酸分子。本公开进一步涉及核酸构建体，如载体和表达盒，其中含有与异源核苷酸序列可操作连接的调控元件。本发明还涉及用转基因稳定转化宿主细胞（如迷宫真菌细胞）的方法。还提供了稳定转化的重组细胞、后代、由此衍生的生物材料以及制备和使用这些材料的方法。
• Promoters and terminators for use in eukaryotic cells
  申请人：Schneider Jane C.

  公开号：US10612034B2

  公开（公告）日：2020-04-07

  The present invention provides novel promoter and terminator sequences for use in heterologous gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a heterologous gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the heterologous gene; and methods for identifying promoters.

  本发明提供了用于真核细胞（如藻类细胞）中异源基因表达的新型启动子和终止子序列。本发明进一步提供了表达盒，该表达盒包括与异源基因可操作连接的本文所述启动子。本发明进一步提供了表达载体和宿主真核细胞，如藻类细胞，用于表达异源基因编码的蛋白质；以及鉴定启动子的方法。