N-(1-methyl-1H-pyrazol-3-yl)-isobutyramide | 62400-46-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(1-methyl-1H-pyrazol-3-yl)-isobutyramide
• 英文别名: 2-Methyl-N-(1-methyl-1H-pyrazol-3-yl)propanamide；2-methyl-N-(1-methylpyrazol-3-yl)propanamide
• CAS: 62400-46-8
• 化学式: C₈H₁₃N₃O
• mdl: MFCD20356058
• 分子量: 167.211
• InChiKey: YDRPFSJAXPBNAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异丁酸酐 、 N-甲基-3-氨基吡唑 在 ether petrol 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 N-(1-methyl-1H-pyrazol-3-yl)-isobutyramide
  参考文献：
  名称：

  Acylaminopyrazoles

  摘要：

  式中Ar代表可选取的取代基的吡唑基团，酰胺基--NR.sup.1 COR.sup.2连接到吡唑环的碳原子上，具有抗过敏活性的Acylamino pyrazolyl化合物，制备这些化合物的方法以及含有这些化合物的制药配方。

  公开号：

  US04166123A1

文献信息

• DIAZAINDOLE-DICARBONYL-PIPERAZINYL ANTIVIRAL AGENTS
  申请人：Bender John A.

  公开号：US20080125439A1

  公开（公告）日：2008-05-29

  The invention comprises substituted diazaindole-dicarbonyl-piperazinyl derivatives of general Formula I wherein: Q is selected from the group consisting of -- may represent a bond; T is —C(O)— or —CH(CN)—; and —Y— is selected from the group consisting of compositions thereof and their use for treating HIV infection.

  该发明涉及一种一般式I的取代的二氮杂吲哌唑-二羧酰基-哌嗪基衍生物，其中：Q选自由以下组成的群：-可能代表键；T为-C（O）-或-CH（CN）-；和-Y-选自由以下组成的群：其组成物及其用于治疗HIV感染的用途。
• DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  申请人：IRM LLC

  公开号：EP1928236B1

  公开（公告）日：2011-11-23
• 2-HETEROARYLAMINO-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
  申请人：IRM LLC

  公开号：EP2190836B1

  公开（公告）日：2011-08-17
• SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
  申请人：GlaxoSmithKline Intellectual Property (No.2) Limited

  公开号：US20170355705A1

  公开（公告）日：2017-12-14

  The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
• US4166123A
  申请人：——

  公开号：US4166123A

  公开（公告）日：1979-08-28