(2S)-1-(2,3-dihydro-4-benzo[b]furanoxy)-3-(4-(3-ethylbenzo[b]thiophen-2-yl)piperidin-1-yl)-2-propanol | 346695-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: (2S)-1-(2,3-dihydro-4-benzo[b]furanoxy)-3-(4-(3-ethylbenzo[b]thiophen-2-yl)piperidin-1-yl)-2-propanol
• 英文别名: (2S)-1-(2,3-dihydro-1-benzofuran-4-yloxy)-3-[4-(3-ethyl-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
• CAS: 346695-62-3
• 化学式: C₂₆H₃₁NO₃S
• 分子量: 437.603
• InChiKey: WRMVPWQWOFKRRB-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-hydroxy-4-(3-ethylbezo[b]thiophen-2-yl)piperidine 、 (S)-(+)-4-(oxiranylmethoxy)-2,3-dihydrobenzo[b]furan 以 甲醇 为溶剂， 反应 18.0h， 以to give the title compound as a clear colorless oil (0.043 g, 35%)的产率得到(2S)-1-(2,3-dihydro-4-benzo[b]furanoxy)-3-(4-(3-ethylbenzo[b]thiophen-2-yl)piperidin-1-yl)-2-propanol
  参考文献：
  名称：

  Benzofuran derivatives

  摘要：

  本发明提供了式（I）的化合物，其可用于治疗抑郁症、焦虑症，并缓解戒烟或尼古丁部分戒断引起的症状。

  公开号：

  US20030232833A1

文献信息

• Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them
  申请人：Bhuniya Debnath

  公开号：US20050113368A1

  公开（公告）日：2005-05-26

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. The present invention also relates to processes for the preparation of the compounds of formula (I), novel intermediates, processes for their preparation, their use in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.

  本发明涉及公式（I）的新型抗糖尿病、降脂、抗肥胖和降胆固醇化合物及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物，以及制备这些化合物的方法。更具体地说，本发明涉及一般的烷基羧酸及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物，以及制备这些化合物的方法。本发明还涉及公式（I）化合物的制备方法、新型中间体的制备方法、以及它们在制备上述化合物和作为抗糖尿病、降脂、抗肥胖和降胆固醇化合物的用途。
• US6844344B2
  申请人：——

  公开号：US6844344B2

  公开（公告）日：2005-01-18
• Benzofuran derivatives
  申请人：——

  公开号：US20030232833A1

  公开（公告）日：2003-12-18

  The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine. 1

  本发明提供了一种化合物，其化学式为（I），可用于治疗抑郁症、焦虑症，并缓解因戒烟或部分戒烟引起的症状。