4-[(3-bromopyridin-4-yl)methyl]morpholine | 1449008-29-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-[(3-bromopyridin-4-yl)methyl]morpholine
• 英文别名: 4-(3-Bromo-pyridin-4-ylmethyl)morpholine
• CAS: 1449008-29-0
• 化学式: C₁₀H₁₃BrN₂O
• 分子量: 257.13
• InChiKey: VKNJQXFLCZNQDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS
  申请人：Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.

  公开号：EP3790873A1

  公开（公告）日：2021-03-17
• [EN] 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS<br/>[FR] COMPOSÉS DE 1H-INDAZOLE-3-CARBOXAMIDE UTILISÉS EN TANT QU'INHIBITEURS DE LA GLYCOGÈNE SYNTHASE KINASE 3 BÊTA
  申请人：ACRAF

  公开号：WO2019215075A1

  公开（公告）日：2019-11-14

  The present invention relates to the 1 H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3β-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) osteoporosis, (viii) cardiac hypertrophy, (ix) epilepsies and (x) neuropathic pain.