(E)-N,N'-di(propan-2-yl)ethene-1,2-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-N,N'-di(propan-2-yl)ethene-1,2-diamine
• 化学式: C₈H₁₈N₂
• 分子量: 142.24
• InChiKey: QXCIXKNYHWHRDG-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Organometallic compounds
  申请人：Meiere Houston Scott

  公开号：US20070299274A1

  公开（公告）日：2007-12-27

  This invention relates to organometallic compounds represented by the formula H a M(NR 1 R 2 ) x (NR 3 H) y (NH 2 ) z wherein M is a metal or metalloid, each of R 1 , R 2 and R 3 is the same or different and is independently a hydrocarbon group or a heteroatom-containing group, a is a value from 0 to 3, x is a value from 0 to 3, y is a value from 0 to 4, z is a value from 0 to 4, and a+x+y+z is equal to the oxidation state of M, provided that at least one of y and z is a value of at least 1, a process for producing the organometallic compounds, and a method for producing a film or coating from organometallic precursor compounds.

  本发明涉及有机金属化合物，其公式表示为HaM（NR1R2）x（NR3H）y（NH2）z，其中M是金属或金属类似物，R1、R2和R3中的每一个相同或不同，且独立地为碳氢基团或含杂原子基团，a的值为0到3，x的值为0到3，y的值为0到4，z的值为0到4，且a+x+y+z等于M的氧化态，但至少y和z中的一个值为至少1，本发明还涉及制备该有机金属化合物的方法，以及从有机金属前体化合物制备薄膜或涂层的方法。
• INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE
  申请人：Cottrell Kevin M.

  公开号：US20080125376A1

  公开（公告）日：2008-05-29

  The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.

  本发明涉及公式I的化合物：或其药学上可接受的盐，其抑制丝氨酸蛋白酶活性，特别是乙型肝炎病毒NS3-NS4A蛋白酶的活性。因此，它们通过干扰乙型肝炎病毒的生命周期来发挥作用，并且可用作抗病毒剂。本发明还涉及药学上可接受的组合物，包括上述化合物，用于体外使用或用于治疗患有HCV感染的患者的给药。本发明还涉及制备该化合物的方法。本发明还涉及通过给予本发明化合物的药物组合物治疗患有HCV感染的患者的方法。
• Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
  申请人：Perni Robert B.

  公开号：US20080311079A1

  公开（公告）日：2008-12-18

  The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.

  本发明涉及抑制丝氨酸蛋白酶活性的化合物，特别是抑制丙型肝炎病毒NS3-NS4A蛋白酶活性的化合物。因此，它们通过干扰丙型肝炎病毒的生命周期来发挥作用，并且也可用作抗病毒药物。本发明还涉及包含这些化合物的组合物，无论是用于体外使用还是用于治疗患有HCV感染的患者的给药。本发明还涉及通过给予包含本发明化合物的组合物来治疗患有HCV感染的患者的方法。本发明还涉及制备这些化合物的工艺。
• ORGANOMETALLIC COMPOUNDS
  申请人：Meiere Scott Houston

  公开号：US20130047890A1

  公开（公告）日：2013-02-28

  This invention relates to organometallic compounds represented by the formula H a M(NR 1 R 2 ) x (NR 3 H) y (NH 2 ) z wherein M is a metal or metalloid, each of R 1 , R 2 and R 3 is the same or different and is independently a hydrocarbon group or a heteroatom-containing group, a is a value from 0 to 3, x is a value from 0 to 3, y is a value from 0 to 4, z is a value from 0 to 4, and a+x+y+z is equal to the oxidation state of M, provided that at least one of y and z is a value of at least 1, a process for producing the organometallic compounds, and a method for producing a film or coating from organometallic precursor compounds.
• US7378422B2
  申请人：——

  公开号：US7378422B2

  公开（公告）日：2008-05-27