hydron;(E)-octadec-9-en-1-amine;fluoride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: hydron;(E)-octadec-9-en-1-amine;fluoride
• 化学式: C18H38FN
• 分子量: 287.5
• InChiKey: QGSCPWWHMSCFOV-RRABGKBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.27
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Process for the Synthesis of Sulfones and Sulfonamides
  申请人：Commissariat a l'Energie Atomique et aux Energies Alternatives

  公开号：US20170166542A1

  公开（公告）日：2017-06-15

  A one pot single step process is described for the synthesis of a compound, including a labeled compound, containing a sulfonyl functional group comprising the step of mixing together a silane, an SO 2 source, an electrophilic compound, an activating compound and optionally a metal catalyst. A process for producing tracers from a labeled sulfonyl containing compound prepared by the described process is also included.

  描述了一种一锅单步法合成化合物的过程，包括含有磺酰基的标记化合物，该过程包括将硅烷、SO2源、亲电性化合物、活化化合物和可选的金属催化剂混合在一起的步骤。还包括一种从通过所述过程制备的含有标记磺酰基的化合物生产示踪剂的过程。
• Amino Acid Derivatives and Their Uses
  申请人：Johnson & Johnson Consumer Inc.

  公开号：US20160145203A1

  公开（公告）日：2016-05-26

  Provided are compounds described by the Formula I: wherein: R 1 is a linear or branched, saturated or unsaturated aliphatic group having from 5 to 22 carbon atoms; R 2 is selected from the group consisting of the functional groups: and salts thererof; n is from 0 to 4; and R 3 is a linear or branched, saturated or unsaturated aliphatic group having from 1 to 6 carbon atoms. Also provided are compositions comprising, and methods of use of, the compounds of the present invention.

  提供的化合物由Formula I描述：其中：R1是具有5到22个碳原子的直链或支链、饱和或不饱和的脂肪族基团；R2选自以下功能基团组成的群体：以及其盐；n为0到4；R3是具有1到6个碳原子的直链或支链、饱和或不饱和的脂肪族基团。还提供了包含本发明化合物的组合物和使用方法。
• Formulations and kit for biometric deposition of apatite on teeth
  申请人：Heraeus Kulzer GmbH

  公开号：US20150072315A1

  公开（公告）日：2015-03-12

  The invention proposes formulations for biomimetic deposition of apatite from a partially elastic shaped body on teeth, whereby the shaped body a) contains at least one mineralization matrix containing a gel that comprises water-soluble phosphates or phosphates that can be hydrolyzed to form water-soluble phosphate ions and has a pH value of 2 to 8, optionally fluorides, and b) the at least one or a second mineralization matrix comprises a second gel having a pH value of 3.5 to 14 comprising calcium ions or compounds releasing calcium ions. Moreover, the method for producing the formulation for the deposition of apatite, in particular of needle-shaped fluorapatite crystals, is claimed. Using the formulations according to the invention, it is feasible to deposit more than or equal to 1 μm apatite, in particular fluorapatite, on tooth surfaces in order to seal or brighten porous tooth surfaces.

  本发明提出了一种仿生沉积磷灰石的配方，用于在牙齿上从部分弹性形状体上沉积磷灰石，其中形状体a）包含至少一个矿化基质，其中包含一种凝胶，该凝胶包括水溶性磷酸盐或可水解成水溶性磷酸盐离子的磷酸盐，并且具有pH值为2至8，可选含氟化物，以及b）所述至少一个或第二个矿化基质包含第二个凝胶，其pH值为3.5至14，包括释放钙离子的钙离子或化合物。此外，还声明了用于制备沉积磷灰石的配方的方法，特别是针状氟磷灰石晶体。使用本发明的配方，可以在牙齿表面沉积大于或等于1μm的磷灰石，特别是氟磷灰石，以封闭或美白多孔牙齿表面。
• Application system for facile 3-dimensional application of medical, cosmetic or drug-containing dental care products
  申请人：Heraeus Kulzer GmbH

  公开号：US20150125824A1

  公开（公告）日：2015-05-07

  The invention discloses a partially elastic shaped body in the form of a negative image of a dental arch containing a matrix based on a gel containing an active substance or a system with a mineralizing effect as well as an application system for the treatment of teeth. The application system comprises an application dental splint that is well-suited for use on the upper and/or lower jaw, whereby the dental splint can accommodate at least one first three-dimensional shaped body that is adapted to the splint and contains a matrix, preferably the dental splint can be deformed by heat. The matrix of the at least one first and optionally further shaped body contains at least one active substance or a system with a mineralizing effect containing phosphates, calcium, and fluorides. The method for producing the application system and a kit comprising the application system are also a subject matter of the invention. According to the invention, the application system and kit are used for depositing apatite, in particular needle-shaped fluorapatite crystals. According to the invention, it is feasible to deposit more than or equal to 1 μm apatite, in particular fluorapatite, on tooth surfaces over one sleeping period or during the day in order to seal or brighten porous tooth surfaces.

  本发明公开了一种部分弹性的形体，其呈负牙弓形状，包含基于含有活性物质或具有矿化效果的凝胶的基质，以及用于治疗牙齿的应用系统。该应用系统包括适用于上颌和/或下颌的应用牙托，其中牙托可以容纳至少一个适应于牙托的第一三维形体，该形体包含基质，优选地，该牙托可以通过加热变形。至少一个第一和可选的进一步形体的基质包含至少一个含有磷酸盐、钙和氟化物的活性物质或具有矿化效果的系统。制造应用系统的方法和包含应用系统的套件也是本发明的主题。根据本发明，应用系统和套件用于沉积磷灰石，特别是针状氟磷灰石晶体。根据本发明，可以在一次睡眠期间或白天沉积大于或等于1μm的磷灰石，特别是氟磷灰石，以密封或使多孔牙齿表面变亮。
• Oral care composition comprising dissolved tin and fluoride
  申请人：Gaba International AG

  公开号：EP2111844A1

  公开（公告）日：2009-10-28

  An oral care composition comprising a liquid phase containing dissolved tin, 200 to 2000 ppm fluoride ions, based on the oral composition, and 5 to 60 % by weight, based on the oral care composition, of a C(3-5) sugar alcohol; characterised in that the content of dissolved tin [Sn] in the liquid phase is at least 1000 ppm, based on the composition, and that the composition comprises an organic acid and ammonium cations of the formula (I):          R-NH+Ra-[(CH2)u-NH+Rb]v-Rc ·     (I) wherein R is a saturated or unsaturated straight-chain hydrocarbon residue of 10 to 20 carbon atoms, v is an integer from 0 to 1, u is an integer from 2 to 3 and Ra, Rb and Rc are independently selected from hydrogen and -CH2CH2OH. The composition is preferably a mouthrinse. These compositions are tested in the treatment or prevention of erosive tooth demineralisation caused by food acids.

  一种口腔护理组合物，包括含有溶解锡的液相、基于口腔组合物的 200 至 2000 ppm 氟离子以及基于口腔护理组合物的 5 至 60 %（重量百分比）的 C(3-5)糖醇；其特征在于，基于组合物，液相中溶解锡[Sn]的含量至少为 1000 ppm，并且该组合物包括一种有机酸和式 (I) 的铵阳离子： R-NH+Ra-[(CH2)u-NH+Rb]v-Rc - (I) 其中 R 是 10 至 20 个碳原子的饱和或不饱和直链烃残基，v 是 0 至 1 的整数，u 是 2 至 3 的整数，Ra、Rb 和 Rc 分别独立地选自氢和-CH2CH2OH。组合物最好是漱口水。这些组合物可用于治疗或预防食物酸引起的腐蚀性牙齿脱矿。