毒理性
先前的研究已经证实，通过表皮应用5-甲基-3-n-十五烷基儿茶酚（5-Me-PDC），这是一种毒藤漆酚成分的合成类似物，可以在小鼠中诱导对3-n-十五烷基儿茶酚（PDC）的免疫耐受。5-Me-PDC诱导耐受性可能是由载体大分子上存在的巯基亲核试剂与来自母体儿茶酚的相应邻醌选择性反应形成的蛋白质共轭介导的。为了进一步研究5-Me-PDC的耐受原性，我们将研究扩展到了通常被接受的用于研究接触性过敏的实验动物——豚鼠。结果表明，毒藤漆酚的特异性免疫耐受性是在应用了PDC类似物的两次表皮之后诱导的。此外，我们能够显示，处理过的动物至少在6周内保持耐受性，这个时间段与静脉注射PDC的O,O-双乙酰衍生物后观察到的时期相当。数据表明，有可能开发出一种对毒藤接触性皮炎具有治疗作用的外用耐受原。
Previous studies have established that epicutaneous application of 5-methyl-3-n-pentadecylcatechol (5-Me-PDC), a synthetic analog of a poison ivy urushiol component, leads to immune tolerance to 3-n-pentadecylcatechol (PDC) in mice. The induction of tolerance by 5-Me-PDC may be mediated by a protein conjugate formed via selective reaction of thiol nucleophiles present on the carrier macromolecule with the corresponding o-quinone derived from the parent catechol. In order to examine further the tolerogenic properties of 5-Me-PDC, we have extended our studies to the guinea pig, the generally accepted experimental species for the study of contact allergy. The results have established that specific immune tolerance to poison ivy urushiol is induced following 2 epicutaneous applications of the PDC analog. Furthermore, we were able to show that the treated animals remained tolerant for at least 6 weeks, a period of time comparable to that observed following the intravenous administration of the O,O-bis-acetyl derivative of PDC. The data point to the possibility of developing a therapeutically effective topical tolerogen for poison ivy contact dermatitis.
来源:Hazardous Substances Data Bank (HSDB)
