3,3-dimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine | 1595279-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 3,3-dimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
• 英文别名: 3,3-dimethyl-1,2-dihydropyrrolo[2,3-b]pyridine
• CAS: 1595279-67-6
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: RKOPPQLAXXNYAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3-二甲基-1H-吡咯并[2,3-b]吡啶-2(3h)-酮 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以73 mg的产率得到3,3-dimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
  参考文献：
  名称：

  [EN] AZAINDOLINES
  [FR] AZAINDOLINES

  摘要：

  揭示了式（I）的化合物或其药用盐，其中W、Y、Z、R1、R2、R3和R4如本申请中所述，并且使用这些化合物治疗癌症的方法。

  公开号：

  WO2014056871A1

文献信息

• Azaindolines
  申请人：Hoffmann-La Roche Inc.

  公开号：US09309248B2

  公开（公告）日：2016-04-12

  Disclosed are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R1, R2, R3 and R4 are as described in this application, and methods of using the compounds in the treatment of cancer.

  本发明公开了式（I）的化合物或其药学上可接受的盐，其中W、Y、Z、R1、R2、R3和R4如本申请所述，并公开了使用这些化合物治疗癌症的方法。
• AZAINDOLINES
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150266879A1

  公开（公告）日：2015-09-24

  Disclosed are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R 1 , R 2 , R 3 and R 4 are as described in this application, and methods of using the compounds in the treatment of cancer.

  本发明涉及式(I)的化合物或其药学上可接受的盐，其中W、Y、Z、R1、R2、R3和R4如本申请所述，并且使用这些化合物治疗癌症的方法。
• Clostridium difficile toxin inhibitors
  申请人：Venenum Biodesign, LLC

  公开号：US10669242B2

  公开（公告）日：2020-06-02

  The present invention relates to benzodiazepine derivative compounds of formula (I), or pharmaceutically acceptable salts thereof. The present benzodiazepine compounds are useful Clostridium difficile inhibitors in the treatment of Clostridium difficile infection in humans. The present invention provides a pharmaceutical composition containing benzodiazepine compounds of formula (I) and a method of making as well as a method of using the same in treating patients infected with Clostridium difficile infection by administering the same. The compounds of the present invention may be used in combination with additional antibiotics or anti-toxin antibody drugs.

  本发明涉及式（I）的苯二氮杂卓衍生物化合物或其药学上可接受的盐类。本发明的苯二氮杂卓化合物是治疗人类艰难梭菌感染的有用的艰难梭菌抑制剂。本发明提供了一种含有式（I）苯并二氮杂卓化合物的药物组合物及其制造方法，以及通过给药治疗感染艰难梭菌的患者的方法。本发明的化合物可与其他抗生素或抗毒素抗体药物联合使用。
• Direct positive dimethine cyanine dyes containing 1-aryl-2-heteroaryl indole nucleus
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0296873B1

  公开（公告）日：1993-09-08
• Novel Clostridium Difficile Toxin Inhibitors
  申请人：Venenum Biodesign, LLC

  公开号：US20190194147A1

  公开（公告）日：2019-06-27

  The present invention relates to benzodiazepine derivative compounds of formula (I), or pharmaceutically acceptable salts thereof. The present benzodiazepine compounds are useful Clostridium difficile inhibitors in the treatment of Clostridium difficile infection in humans. The present invention provides a pharmaceutical composition containing benzodiazepine compounds of formula (I) and a method of making as well as a method of using the same in treating patients infected with Clostridium difficile infection by administering the same. The compounds of the present invention may be used in combination with additional antibiotics or anti-toxin antibody drugs.