1,6-Dichlor-2,5-dimethylhexan | 90600-90-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 1,6-Dichlor-2,5-dimethylhexan
• 英文别名: 2,5-Dichloromethylhexane；1,6-dichloro-2,5-dimethylhexane
• CAS: 90600-90-1
• 化学式: C₈H₁₆Cl₂
• 分子量: 183.121
• InChiKey: WTXHEJVAQGEHFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  3-氯-2-甲基丙烯 在 氢氧化钾 、 硼烷四氢呋喃络合物 作用下， 生成 1,6-Dichlor-2,5-dimethylhexan
  参考文献：
  名称：

  Schlegel, Guenter; Schaefer, Hans J., Chemische Berichte, 1984, vol. 117, # 4, p. 1400 - 1423

  摘要：

  DOI：

文献信息

• Non-peptide GnRH agents, methods and intermediates for their preparation
  申请人：Pfizer Inc.

  公开号：US20040010033A1

  公开（公告）日：2004-01-15

  Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

  描述了能够抑制促性腺激素释放激素作用的非肽类GnRH药物。这些化合物及其药用盐、多聚体、前药和活性代谢物适用于治疗哺乳动物的生殖障碍和类固醇激素依赖性肿瘤，以及调节生育能力，其中指示抑制促性腺激素释放。还描述了合成这些化合物和在其制备中有用的中间体的方法。
• [EN] NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE<br/>[FR] AGENTS ANTI-GNRH NON PEPTIDIQUES, COMPOSITIONS PHARMACEUTIQUES ET PROCEDES D'UTILISATION
  申请人：PFIZER

  公开号：WO2003106446A1

  公开（公告）日：2003-12-24

  Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression o£ gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

  描述了能够抑制促性腺激素释放激素作用的非肽类GnRH药物。这些化合物及其药用可接受的盐类、前药和活性代谢物适用于治疗哺乳动物的生殖障碍和类固醇激素依赖性肿瘤，以及调节生育能力，其中表明需要抑制促性腺激素释放。还描述了合成这些化合物和在其制备中有用的中间体的方法。
• Non-peptide GnRH agents, pharmaceutical compositions and methods for their use
  申请人：Agouron Pharmaceuticals, Inc.

  公开号：US20040014787A1

  公开（公告）日：2004-01-22

  Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

  本文描述了能够抑制促性腺激素释放激素作用的非肽类GnRH（促性腺激素释放激素）药物。这些化合物及其药学上可接受的盐、前药和活性代谢物适用于治疗哺乳动物生殖障碍和类固醇激素依赖性肿瘤，以及调节生育，其中需要抑制促性腺激素释放。本文还描述了合成这些化合物和其制备中有用的中间体的方法。
• Process for preparing 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphtalene
  申请人：Union Camp Corporation

  公开号：EP0380288A1

  公开（公告）日：1990-08-01

  A process is disclosed for the production of 1,1,3,4,4,6-Hexamethyl-1,2,3,4-Tetrahydronaphthalene comprising reacting para-cymene with an olefinic compound selected from the group consisting of 2,3-dimethyl-1-­butene and neohexene, in the presence of a reagent of the formula and further in the presence of an aluminum halide and I₂, wherein in the above formula, R¹, R², R³, R⁴, R⁵ and R⁶, independently, are H or a C₁-C₃ straight chain, or branched alkyl, provided that no more than one of R¹, R² and R³ are H, and no more than one of R⁴, R⁵ and R⁶ are H. The subject process produces the desired compound in a surprisingly high yield, with a surprisingly high selectivity, and at a relatively high rate of reaction, using better, more convenient and/or less expensive process methodology than many processes known heretofore. Using the subject process, one is able to efficiently and effectively produce HMT, a compound of extreme importance to the fragrance industry.

  本发明公开了一种用于生产 1,1,3,4,4,6-六甲基-1,2,3,4-四氢萘的工艺，该工艺包括对位二茂萘与选自由 2,3-二甲基-1-丁烯和新己烯组成的组中的烯烃化合物，在存在下式试剂的情况下，以及在存在卤化铝和 I₂ 的情况下进行反应。 其中，在上式中，R¹、R²、R³、R⁴、R⁵ 和 R⁶分别为 H 或 C⁶、是 H 或 C₁-C₃ 直链或支链烷基，但 R¹、R² 和 R³ 中不能有一个以上是 H，R⁴、R⁵ 和 R⁶ 中不能有一个以上是 H。 与迄今已知的许多工艺相比，本发明的工艺能以令人惊讶的高产率、高选择性和相对较高的反应速率生产出所需的化合物，其工艺方法更好、更方便和/或更便宜。使用本发明的工艺，人们可以高效地生产 HMT（一种对香料工业极为重要的化合物）。
• Process for preparing polyalkyl tetrahydronaphthalenes
  申请人：Union Camp Corporation

  公开号：EP0381353A1

  公开（公告）日：1990-08-08

  A process is disclosed for the production of polyalkyl tetrahydronaphthalenes where a cyclialkylation reaction between an olefinic compound of the general Formula and a substituted benzene compound is carried out in the presence of a hydride abstracting reagent, a Lewis acid, and, optionally, a phase transfer agent. In some embodiments, the subject process is specifically carried out in the absence of elemental iodine. The subject process, which may be practiced in an unhalogenated hydrocarbon solvent, produces the desired compounds in a surprisingly high yield, with a surprisingly high selectivity to the desired product, and a relatively high rate of reaction, using better, more convenient or less expensive process methodology than many processes known heretofore.

  本发明公开了一种生产多烷基四氢萘的工艺，在该工艺中，通式烯烃化合物与取代苯化合物之间的环烷基化反应是在氢化物抽取试剂、路易斯酸和可选的相转移剂存在下进行的。在某些实施方案中，主体工艺具体是在没有碘元素的情况下进行的。与迄今已知的许多工艺相比，本发明的工艺可在非卤代烃溶剂中进行，能以令人惊讶的高产率生产出所需的化合物，对所需产物具有令人惊讶的高选择性和相对较高的反应速率，并采用更好、更方便或更便宜的工艺方法。