5-Amino-7-(5-bromo-2-hydroxyphenyl)-2-[(5-bromo-2-hydroxyphenyl)methylene]-3-o xo-4,7-dihydro-1,3-thiazolidino[3,2-a]pyridine-6,8-dicarbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-Amino-7-(5-bromo-2-hydroxyphenyl)-2-[(5-bromo-2-hydroxyphenyl)methylene]-3-o xo-4,7-dihydro-1,3-thiazolidino[3,2-a]pyridine-6,8-dicarbonitrile
• 英文别名: (2Z)-5-amino-7-(5-bromo-2-hydroxyphenyl)-2-[(5-bromo-2-hydroxyphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile
• 化学式: C₂₂H₁₂Br₂N₄O₃S
• 分子量: 572.2
• InChiKey: JEVZVNWWWPIYHH-FXBPXSCXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  160
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION
  申请人：Mullan Michael J.

  公开号：US20100119599A1

  公开（公告）日：2010-05-13

  Provided are methods of treating or reducing the risk of developing beta-amyloid production, beta-amyloid deposition, beta-amyloid neurotoxicity (including abnormal hyperphosphorylation of tau) and microgliosis associated with cerebral accumulation of Alzheimer's amyloid by administering therapeutically effective amounts of polyhydroquinoline and dihydropyridine compounds which decrease Abeta production in cells. Further provided are methods for diagnosing diseases associated with cerebral accumulation of Alzheimer's amyloid in animals or humans by administering diagnostically effective amounts of polyhydroquinoline and dihydropyridine compounds which decrease Abeta production in cells.
• [EN] ENTPD5 INHIBITORS<br/>[FR] INHIBITEURS DE ENTPD5
  申请人：UNIV TEXAS

  公开号：WO2012065139A2

  公开（公告）日：2012-05-18

  The invention provides methods and pharmaceutical compositions for treating cancer or promoting apoptosis of cancer cells, or reducing the resistance of cancer cells to chemotherapy or apoptosis-promoting therapies by contacting the cancer cells with an ENTPD5-specific inhibitor.