(2S,3R,4S,5R)-2-{[(4aR,5'R,5aS,7aR,7bR,10S,11aS,12aS,12bS,14aR)-4'-hydroxy-1,1,5',7a,8,12a-hexamethylhexadecahydro-2H-spiro[cyclopropa[1',8a']naphtho[2',1':4,5]indeno[2,1-b]pyran-10,2'-[3,6]dioxabicyclo[3.1.0]hexan]-2-yl]oxy}tetrahydro-2H-pyran-3,4,5-trio

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (2S,3R,4S,5R)-2-{[(4aR,5'R,5aS,7aR,7bR,10S,11aS,12aS,12bS,14aR)-4'-hydroxy-1,1,5',7a,8,12a-hexamethylhexadecahydro-2H-spiro[cyclopropa[1',8a']naphtho[2',1':4,5]indeno[2,1-b]pyran-10,2'-[3,6]dioxabicyclo[3.1.0]hexan]-2-yl]oxy}tetrahydro-2H-pyran-3,4,5-trio
• 英文别名: (2S,3R,4S,5R)-2-[(1R,1'S,4'R,5S,5'R,6'R,10'S,12'S,13'S,16'R,21'R)-2-hydroxy-1,4',6',12',17',17'-hexamethylspiro[3,6-dioxabicyclo[3.1.0]hexane-4,8'-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docosane]-18'-yl]oxyoxane-3,4,5-triol
• 化学式: C₃₅H₅₄O₉
• 分子量: 618.8
• InChiKey: RKNTVINERUAWJC-LXVMFROXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  44
• 可旋转键数：
  2
• 环数：
  9.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
  申请人：Satori Pharmaceuticals, Inc.

  公开号：EP1888616A1

  公开（公告）日：2008-02-20
• SYNTHESIS OF COMPOUNDS USEFUL AS MODULATORS OF AMYLOID-BETA PRODUCTION
  申请人：Satori Pharmaceuticals, Inc.

  公开号：EP2073638B1

  公开（公告）日：2013-05-15
• Compounds useful for treating neurodegenerative disorders
  申请人：Findeis A. Mark

  公开号：US20070010503A1

  公开（公告）日：2007-01-11

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
• US7851641B2
  申请人：——

  公开号：US7851641B2

  公开（公告）日：2010-12-14
• US8263755B2
  申请人：——

  公开号：US8263755B2

  公开（公告）日：2012-09-11