Phthalazine, 6-(1-methylethyl)- | 122882-99-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Phthalazine, 6-(1-methylethyl)-
• 英文别名: 6-propan-2-ylphthalazine
• CAS: 122882-99-9
• 化学式: C₁₁H₁₂N₂
• 分子量: 172.23
• InChiKey: OVBJAABCEPSUNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Aminooxazole Inhibitors of Cyclin Dependent Kinases
  申请人：Desai Laxman S.

  公开号：US20120302578A1

  公开（公告）日：2012-11-29

  Oxazole derivatives are described. The inventive compounds are useful as kinase inhibitors, and may be used in the treatment of cancer, such as prostate cancer, lung cancer, breast cancer, colon cancer, leukemia, CNS cancer, melanoma, ovarian cancer, and renal cancer.

  噁唑衍生物被描述。这些创新化合物可用作激酶抑制剂，并可用于治疗癌症，如前列腺癌、肺癌、乳腺癌、结肠癌、白血病、中枢神经系统癌症、黑色素瘤、卵巢癌和肾癌。
• Bis-aryl amide compounds and methods of use
  申请人：Dimauro F. Erin

  公开号：US20070072862A1

  公开（公告）日：2007-03-29

  The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one embodiment, the compounds have a general Formula I wherein A 1 , A 2 , A 3 , A 4 , L, R 1 , R 2 and R 3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of the present invention, methods of use such as treatment of Lck and/or c-Kit kinase mediated diseases by administering the compounds of the invention, or compositions including one or more compounds of the invention, and intermediates and processes useful for the preparation of compounds of the present invention.

  本发明涵盖了一类新的化合物，用于预防和治疗蛋白激酶介导的疾病，包括自身免疫疾病和炎症。在一个实施例中，这些化合物具有一般的化学式I，其中A1、A2、A3、A4、L、R1、R2和R3在此处定义。本发明还涵盖了包括本发明的一种或多种化合物的药物组合物，使用方法如通过给予本发明的化合物治疗Lck和/或c-Kit激酶介导的疾病，或包括本发明的一种或多种化合物的组合物，以及用于制备本发明化合物的中间体和方法。
• Method for producing grains of aliphatic acid silver salt and thermally processed image recording material
  申请人：——

  公开号：US20010018170A1

  公开（公告）日：2001-08-30

  A method for producing grains of aliphatic acid silver salt by mixing a solution containing silver ions and a solution of aliphatic acid alkali metal salt to attain reaction of them, wherein (1) 95-100% of the total molar number to be added of the aliphatic acid alkali metal salt is added under a condition that dilution factor of the solution of aliphatic acid alkali metal salt becomes 10-fold or higher at 1 second after the addition, (2) 95-100% of the total amount to be added of silver in the solution containing silver ions is added under a condition that dilution factor of the solution containing silver ions becomes 20-fold or higher at 1 second after the addition, and (3) 50-100% of the total amount to be added of the solution of aliphatic acid alkali metal salt is added simultaneously with the solution containing silver ions. According to the present invention, there is provided a method for producing grains of aliphatic acid silver salt, which show excellent fog prevention ability, in addition, excellent fog prevention ability even after time lapse, when used in a thermally processed image recording material.

  本发明提供了一种制备脂肪族酸银盐颗粒的方法，包括将含有银离子的溶液和脂肪族酸碱金属盐的溶液混合以使它们反应，其中（1）脂肪族酸碱金属盐的总摩尔数的95-100％在加入后1秒钟时，脂肪族酸碱金属盐的稀释因子变为10倍或更高，（2）所含银离子的溶液中总添加量的95-100％在加入后1秒钟时，银离子溶液的稀释因子变为20倍或更高，（3）脂肪族酸碱金属盐溶液的总添加量的50-100％同时与含银离子的溶液一起加入。该发明提供了一种制备脂肪族酸银盐颗粒的方法，该颗粒具有出色的防雾能力，并且即使在时间流逝后，当用于热处理的图像记录材料时，仍具有出色的防雾能力。
• Method for preparing non-photosensitive fatty acid silver salt grains and an apparatus for preparing the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20030023103A1

  公开（公告）日：2003-01-30

  A method for preparing non-photosensitive fatty acid silver salt grains was disclosed. The method has the step of reacting a silver ion-containing solution, the solvent of which being water or a mixture of water and an organic solvent, with a solution of a fatty acid alkali metal salt, the solvent of which being water, an organic solvent, or a mixture of water and an organic solvent, to obtain fatty acid silver salt grains; in which the reaction is proceeded by mixing the silver ion-containing solution and the solution of the fatty acid alkali metal salt within a closed mixing means. The dispersion of the non-photosensitive fatty acid silver salt grains prepared according to such method is excellent in dispersion stability and coating property.

  本发明公开了一种制备非感光脂肪酸银盐颗粒的方法。该方法包括以下步骤：将含有银离子的溶液与一种脂肪酸碱金属盐的溶液反应，其中溶剂为水或水和有机溶剂的混合物，而脂肪酸碱金属盐的溶剂为水、有机溶剂或水和有机溶剂的混合物，以获得脂肪酸银盐颗粒；在封闭的混合装置中混合含银离子的溶液和脂肪酸碱金属盐的溶液进行反应。根据这种方法制备的非感光脂肪酸银盐颗粒的分散性和涂层性能都非常优秀。
• Bisphenol-phosphorous compound complex and thermally processed image recording material utilizing the same
  申请人：——

  公开号：US20020009683A1

  公开（公告）日：2002-01-24

  Bisphenol-phosphorus compound complexes represented by the following general formula (1) are disclosed (R 1 to R 4 represent hydrogen atom or a group that can be a substituent on a benzene ring; L represents —S— group or a —CHR 5 — group where R 5 represents hydrogen atom or an alkyl group; and R 6 to R 8 represent an alkyl group, an aryl group, a heterocyclic group etc.). The present invention provides reducing agents that can realize thermally processed image recording materials that can provide sufficient image density at a practical reaction temperature (specifically 100-140° C.) and within a practical reaction time (specifically 1-30 seconds), and can sufficiently suppress the coloration of white portions when the materials are stored in a dark place after the development.

  本发明揭示了以下一般式（1）所代表的双酚-磷化合物配合物（其中R1至R4代表氢原子或苯环上可取代基团；L代表—S—基团或—CHR5—基团，其中R5代表氢原子或烷基；R6至R8代表烷基、芳基、杂环基等）。本发明提供了还原剂，可以实现在实际反应温度（具体为100-140℃）和实际反应时间（具体为1-30秒）内提供足够的图像密度的热处理图像记录材料，并且在开发后在暗处存储材料时可以充分抑制白色部分的着色。