6-(2-Methylpropyl)phthalazine | 221118-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(2-Methylpropyl)phthalazine
• CAS: 221118-74-7
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.25
• InChiKey: XNAOFFIFVKGYRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NITROGEN CONTAINING BICYCLIC DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
  申请人：Laboratorios del Dr. Esteve, S.A.

  公开号：EP3339307A1

  公开（公告）日：2018-06-27

  The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).

  本发明涉及新的式（I）化合物： 对电压门控钙通道（VGCC）的α2δ亚基，特别是电压门控钙通道的α2δ-1亚基表现出极大的亲和力和活性，或对电压门控钙通道（VGCC）的α2δ亚基，特别是电压门控钙通道的α2δ-1亚基和去甲肾上腺素转运体（NET）表现出双重活性。
• Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
  申请人：Global Blood Therapeutics, Inc.

  公开号：US10806733B2

  公开（公告）日：2020-10-20

  Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

  本文提供了可作为血红蛋白异位调节剂的取代苯甲醛及其衍生物、制备它们的方法和中间体、包含这些调节剂的药物组合物，以及将它们用于治疗由血红蛋白介导的疾病和可从增加组织含氧量中获益的疾病的方法。
• ANTI-CORROSION AGENTS FOR TRANSPARENT CONDUCTIVE FILM
  申请人：Carestream Health, Inc.

  公开号：EP2547735A1

  公开（公告）日：2013-01-23
• EP2547735B1
  申请人：——

  公开号：EP2547735B1

  公开（公告）日：2016-03-16
• SUBSTITUTED OXAZOLE- AND THIAZOLE-BASED CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS II
  申请人：MEDIFRON DBT INC.

  公开号：EP3224252B1

  公开（公告）日：2019-01-09